Chlamydia trachomatisによる男子尿道炎の臨床的検討

Abstract

1986年1月から1年間の男性新患症例中, 性行為による尿道炎を疑った132例に対してモノクローナル抗体を用いた蛍光抗体直接法(Micro Trak(R))によるC. trachomatisの検索を行った.C. trachomatis陽性例は59例で, 淋菌性尿道炎(GU)26例中の8例, 非淋菌性尿道炎(NGU) 106例中51例であった.clamydia尿道炎(NGU-C)患者の年齢は16歳～52歳(平均30.9歳)であった.感染源は玄人が82例62.7%, 素人23.5%で, GU例との差はみられなかった.NGU-Cの潜伏期間では8～14日にピーク(29.4%)をもち, 4週以上のものも23.5%にみられた.初尿中白血球数では0～9個/hpfまでの例が70.6%を占めていた.38例のNGU-Cに対してOfloxacin 600 mg/dayを5～14日間投与した結果, 全例C. trachomatisの陰性化を得た

From January through December 1986, the urethral smear specimens from 132 male urethritis patients were examined by using Chlamydia trachomatis direct specimen test (Micro Trak). C. trachomatis was detected in 59 (44.7%) out of 132 male urethritis patients, 8 (30.8%) out of 26 patients with gonococcal urethritis (GU), and 51 (48.1%) out of 106 patients with non-gonococcal urethritis (NGU). In 5 (31.3%) out of 16 cases, already treated in other hospitals, infection of C. trachomatis was revealed. The age distribution of the patients with chlamydial urethritis (NGU-C) was between 19 and 52 years old, and the average was 30.9 years old. The peak incubation periods of GU and NGU-C were seen within 7 days and between 8 and 14 days, respectively. In NGU-C patients, 70.6% of them showed WBC less than or equal to 9/hpf in first voided urine sediment. The source of infection was a non-prostitute in 22.2% and a prostitute in 72.2% of GU, while in NGU-C 23.5% was infected from a non-prostitute, and 62.7% from a prostitute. Ofloxacin (OFLX) was administered in a daily dosage of 600 mg (in 3 divided oral doses) for 5 to 14 days in 38 NGU-C patients, and C. trachomatis was eliminated in all cases after the treatment.