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タイトル: | Hydroxypropylcellulosumを用いたPeplomycin膀胱内注入療法 臨床効果について |
その他のタイトル: | A new clinical trial in intravesical chemotherapy with instillation of peplomycin preparation as an emulsion in hydroxypropylcellulosum--preliminary study of patients with bladder tumor |
著者: | 浅川, 正純 前川, たかし 仲谷, 達也 堀井, 明範 安本, 亮二 岸本, 武利 前川, 正信 |
著者名の別形: | ASAKAWA, Masazumi MAEKAWA, Takashi NAKATANI, Tatsuya HORII, Akinori YASUMOTO, Ryoji KISHIMOTO, Taketoshi MAEKAWA, Masanobu |
キーワード: | Hydroxypropylcellulosum Peplcmycin Bladder tumor |
発行日: | Jan-1989 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 35 |
号: | 1 |
開始ページ: | 39 |
終了ページ: | 42 |
抄録: | 1)膀胱癌6例に対してHPC-PEP膀胱内注入療法を行い, 著効1例, 有効2例, やや有効2例, 無効1例の結果を得た.2) HPC-PEP膀胱内注入後の血中および尿中のPEP濃度を経時的に測定した結果, 血中移行はほとんどなく, 尿中排出は注入後3日目まで続く A new peplomycin (PEP) preparation was employed as an emulsion form in hydroxypropylcellulosum (HPC), which is familiar to have a liniment effect with a strong affinity to mucosa of the organ, in the management of 6 patients with bladder tumors. This emuled PEP in HPC (HPC-PEP) was instillated and thereafter, maintained for at least 2 hours at the frequency of once a week. All 6 patients had histopathologically confirmed T1 or T2 transitional cell carcinoma on biopsied specimen. The histological grading of the tumors were divided to 2 in G1, 3 in G2, and 1 in G3 of transitional cell carcinoma. The instillated agent was prepared from the mixture of 15 ml of 6% HPC and 90 mg PEP in 15 ml saline prior to use. A response to this treatment was evaluated primarily by cystoscopic findings and urine cytology 7 days after the instillation. In the present study, the beneficial effects of this treatment were briefly segregated into 4 categories as follows: excellent, good, fair and no responses were referred respectively to as complete eradication of visible tumor with negative urine cytology, a complete disappearance of the primary tumor with a persistent positive cytology, regression of the tumor size and no change of the primary tumor with sustained positive cytology. According to this estimation, 6 patients were categorized to 1 in excellent, 2 in good, 2 in fair and 1 in no responses to this new therapeutic preparation. Furthermore, urinary and serum levels of PEP were determined daily for 7 days after the instillation.(ABSTRACT TRUNCATED AT 250 WORDS) |
URI: | http://hdl.handle.net/2433/116409 |
PubMed ID: | 2471398 |
出現コレクション: | Vol.35 No.1 |
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