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Title: 尿路上皮癌に対するVincristine, Peplomycin,Methotrexate, cis-Diamminedichloroplatinum (2),Adriamycin併用療法(VPM-CisA療法)
Other Titles: Sequential combination chemotherapy consisting of vincristine, peplomycin, methotrexate, cis-diamminedichloroplatinum (II) and adriamycin in urothelial cancer
Authors: 神波, 照夫  KAKEN_name
若林, 賢彦  KAKEN_name
金, 哲將  KAKEN_name
石田, 章  KAKEN_name
新井, 豊  KAKEN_name
小西, 平  KAKEN_name
朴, 勺  KAKEN_name
竹内, 秀雄  KAKEN_name
友吉, 唯夫  KAKEN_name
渡辺, 仁  KAKEN_name
尾松, 操  KAKEN_name
山内, 民男  KAKEN_name
国保, 昌紀  KAKEN_name
Author's alias: KONAMI, Teruo
WAKABAYASHI, Yoshihiko
KIM, Tessho
ISHIDA, Akira
ARAI, Yutaka
KONISHI, Taira
PAK, Kyun
TAKEUCHI, Hideo
TOMOYOSHI, Tadao
WATANABE, Jin
OMATSU, Misao
YAMAUCHI, Tamio
KOKUHO, Masanori
Keywords: Combination chemotherapy
Urothelial cancer
Issue Date: Feb-1989
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 35
Issue: 2
Start page: 231
End page: 237
Abstract: The VPM-CisA (vincristine (VCR), peplomycin (PLM), methotrexate (MTX), cisplatin (CDDP) and doxorubicin (ADM), regimen was used to treat 33 patients with urothelial tract tumors. Twenty-two patients had bi-dimensionally measurable disease parameters and 11 patients with locally advanced tumors were given postoperative adjuvant chemotherapy. The protocol consisted of 0.6 mg/m2 VCR on days 1 and 3, 3 mg/m2 PLM on days 1 to 4, 3 mg/m2 MTX on days 2 and 4, 35 mg/m2 CDDP on day 4, and 20 mg/m2 ADM on day 5. These doses were adjusted for each case: the above mentioned dose x [(80/(40+Age]2 +[(Karnofsky's performance status/100)2]. Of these patients, 28 (86 percent) were treated adequately, including 8 (36 per cent) who achieved a complete (2) or partial (6) remission. The mean duration of survival was 65.2 weeks for complete and partial responders, and 48.8 weeks for non-responders, which was not a statistically significant difference. Of 11, who were given post-operative adjuvant chemotherapy (mean observation period: 83.5 weeks) 9 were alive without evidence of disease, 1 had a recurrence 8 months after first chemotherapy, 1 died due to pulmonary and liver metastasis 2 years after the chemotherapy. Toxicity included mild myelosupression, moderate anorexia, vomiting, and severe gastric ulcer, pulmonary fibrosis.
URI: http://hdl.handle.net/2433/116442
PubMed ID: 2472048
Appears in Collections:Vol.35 No.2

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