神経性頻尿に対する塩酸テロジリンの臨床的検討

Abstract

神経性頻尿19例に対し, TD-758 (12 mg錠)1日2錠投与を行い, 排尿回数の変化, 自覚的改善度, 副作用について検討した.Wash out期間, 対照観察期間は約1週間とし, 投薬観察期間は4週間とした.1)排尿回数については, 投与1週目より有意(p<0.05)に減少し, 4週目では平均1日2回と有意(<0.001)に排尿回数が減少した.2)自覚的改善度は, 著明改善3例, 改善9例, 不変7例で, 改善以上は12例であった.3) 4例に口渇, 2例に腹部膨満感を認めたが, 期間中に投与の中止を必要とする重篤な副作用は認めなかった

TD-758 (12 mg tablets) was given in two tablets daily to 19 patients with nervous pollakisuria. The changes in frequency of daily micturition and in subjective symptoms were studied referring to the diary kept by each patient, along with the occurrence of side effects. Before the medication, urodynamic studies were made on each patient and all the cases were thus confirmed being free from detrusor instability or uninhibited contraction. The wash-out period of other drugs and control observation period, each one week, were set before the medication period which lasted for four weeks. The frequency of micturition per day showed a significant decrease from the first week of the medication period (p less than 0.05), and at the fourth week there was noted a significant reduction by twice per day on the average (p less than 0.001). Subjective efficacy was noted as follows: excellent in 3 cases (15.8%), good in 9 cases (47.7%), unchanged in 7 cases (36.8%), and thus 12 cases (63.2%) showed an efficacy of the rating of good or higher. In four cases dry mouth and in two cases sense of abdominal distention were noted out of the total of 19 cases, but no side effects of severe degree to stop the medication were noted during the medication period. In conclusion TD-758 is a clinically useful remedy for treatment of nervous pollakisuria.