淋菌性尿道炎に対するNorHoxacinの使用経験

Abstract

56例の男子淋菌性尿道炎に対しNFLX, 600 mg/dayを7日間投与し, 3日目, 7日目にその効果を検討した.3日目で77.8%著効, 7日目に94.4%が著効であり7日目までに100%有効と認められた.淋菌のMICを14株についてAMPCおよびNFLXについて測定した.AMPC, NFLXともに耐菌性は見られなかったが, NFLXはAMPCに比べMICの中央値は全体に低い値(0.05 μg/ml)を示した

Fifty six males with gonococcal urethritis were administered 600 mg of norfloxacin (NFLX) daily for 7 days, before the effects were examined. The pharmaceutical effects were studied on the third and the seventh day after administration. Pronounced effectiveness of 77.8%, effectiveness of 19.4% and ineffectiveness of 2.8% were found on the third day after administration, and pronounced effectiveness of 94.4%, effectiveness of 5.6% and ineffectiveness of 0% were found on the seventh day after administration. Effectiveness of 100% was obtained up to the seventh day. Minimum inhibitory concentration (MIC) of NFLX and ampicillin (AMPC) were determined for 14 strains. The peak of MIC of NFLX was found at 0.05 micrograms/ml and all strains were 0.78 micrograms/ml or lower. The peak of MIC of AMPC was 0.1 microgram/ml. MICs of both drugs were 0.78 micrograms/ml or lower, and resistant bacteria were not found. In view of the analyses of age distribution of patients and source of infection, the peak was found in the twenties and the source of infection in 64.7% were, so-called, professional women.