急性精巣上体炎に対するNorfloxacin (NFLX)の臨床検討

Abstract

急性精巣上体炎20例に, NFLXを1回200 mg 1日3回14日間投与し, その臨床効果および安全性につき検討した.1) 7日目で著効9例, 有効10例, 無効1例で有効率95%であった.14日目では著効12例, 有効6例, 無効1例で有効率95%であった.2) 14日目では, 発熱, 疼痛, 腫脹すべて消失したものが8例(7日目では2例)と多く, 7日目に比し効果の増大が認められた.3)投与前膿尿の認められたものは, 20例中13例.尿培養陽性は13例中4例であった.これら膿尿および細菌尿に対しても, 本剤はすぐれた効果を示した.4)末梢血中白血球数, 血沈値, CRPについても本剤投与により, 全般に明らかな改善が認められた.5)自他覚副作用および臨床検査値異常変動は全例で認められなかった

The efficacy and safety of Norfloxacin were studied in the treatment of 20 patients with acute epididymitis. Norfloxacin was orally administered at a dose of 200 mg 3 times a day for 14 days. Clinical efficacy rate on the 7th day was 95% (19/20), excellent in 9 cases, moderate in 10 cases and poor in 1 case, and on the 14th day was 95% (18/19), excellent in 12 cases, moderate in 9 cases and poor in 1 case. On the 14th day, fever, pain and swelling had disappeared in 8 cases (in 2 cases on the 7th day). The efficacy on the 14th day was further investigated compared to that on the 7th day. Before treatment with Norfloxacin, in 13 of the 20 patients, pyuria was observed. Cultivating the bacteria was isolated in 4 of the 13 patients. Norfloxacin remarkably affected the treatment of these patients with pyuria and bacteriuria. In the treatment with Norfloxacin, the count of leukocytes, erythrocyte sedimentation rate and CRP were obviously improved. Side effects and abnormal clinical laboratory findings were not observed. From these results, Norfloxacin 600 mg/day, t.i.d was considered useful and safe in the treatment of acute epididymitis.