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Title: 膀胱腫瘍患者の末梢血リンパ球サブセットについての検討
Other Titles: A study of peripheral blood lymphocyte subsets in patients with bladder tumors
Authors: 松田, 久雄  KAKEN_name
中西, 淳  KAKEN_name
石原, 浩  KAKEN_name
上島, 成也  KAKEN_name
辻橋, 宏典  KAKEN_name
秋山, 隆弘  KAKEN_name
栗田, 孝  KAKEN_name
Author's alias: MATSUDA, Hisao
UMEJIMA, Shigeya
AKIYAMA, Takahiro
KURITA, Takashi
Keywords: Bladder tumor
Lymphocyte subsets
OKT 4/OKT 8 ratio
Leu 7
Issue Date: Jul-1989
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 35
Issue: 7
Start page: 1129
End page: 1134
Abstract: 膀胱腫瘍患者を対象に,末梢血リンパ球サブセットの解析を行った.1)膀胱腫瘍患者と正常者との間に,T cellとB cellの比率に明らかな関係はなかった.2)腫瘍間でみると,浸潤性腫瘍は,表在性腫瘍に比べてOKT8の増加,OKT4/OKT8比の低下を認め,浸潤性腫瘍における細胞性免疫能の低下が示唆された.3)膀胱腫瘍患者では,正常者に比べNK細胞数の低下を認めるとともに,腫瘍深達度が高くなるにつれてNK細胞数の低下を認めた
The analysis of peripheral blood lymphocytic subpopulations was conducted with 16 bladder tumor patients. Lymphocytes were collected centrifugally from the peripheral blood of preoperative patients with bladder tumors, and measured by means of flow cytometry. Among the stages of the bladder tumor patients, there were no clear relationships in the ratio between T cells and B cells. However, with the progression in stages a rise in OKT 8, as well as the lowering of the OKT 4/OKT 8 ratio were discerned. In relation to pTis, Leu 7 showed a higher value than that in other groups with advanced invasion. This suggests that in measurements of lymphocyte subsets in peripheral blood, it will to a certain extent be possible to estimate the preoperative immunological competence of bladder tumor patients.
PubMed ID: 2801404
Appears in Collections:Vol.35 No.7

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