膀胱腫瘍患者の末梢血リンパ球サブセットについての検討

Abstract

膀胱腫瘍患者を対象に, 末梢血リンパ球サブセットの解析を行った.1)膀胱腫瘍患者と正常者との間に, T cellとB cellの比率に明らかな関係はなかった.2)腫瘍間でみると, 浸潤性腫瘍は, 表在性腫瘍に比べてOKT8の増加, OKT4/OKT8比の低下を認め, 浸潤性腫瘍における細胞性免疫能の低下が示唆された.3)膀胱腫瘍患者では, 正常者に比べNK細胞数の低下を認めるとともに, 腫瘍深達度が高くなるにつれてNK細胞数の低下を認めた

The analysis of peripheral blood lymphocytic subpopulations was conducted with 16 bladder tumor patients. Lymphocytes were collected centrifugally from the peripheral blood of preoperative patients with bladder tumors, and measured by means of flow cytometry. Among the stages of the bladder tumor patients, there were no clear relationships in the ratio between T cells and B cells. However, with the progression in stages a rise in OKT 8, as well as the lowering of the OKT 4/OKT 8 ratio were discerned. In relation to pTis, Leu 7 showed a higher value than that in other groups with advanced invasion. This suggests that in measurements of lymphocyte subsets in peripheral blood, it will to a certain extent be possible to estimate the preoperative immunological competence of bladder tumor patients.