Access count of this item: 602

Files in This Item:
File Description SizeFormat 
35_1125.pdf285.57 kBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.author安本, 亮二ja
dc.contributor.author田中, 重入ja
dc.contributor.author川嶋, 秀紀ja
dc.contributor.author柿木, 宏介ja
dc.contributor.author井関, 達男ja
dc.contributor.author梅田, 優ja
dc.contributor.author田部, 茂ja
dc.contributor.author西阪, 誠泰ja
dc.contributor.author浅川, 正純ja
dc.contributor.alternativeYASUMOTO, Ryojija
dc.contributor.alternativeTANAKA, Shigetoja
dc.contributor.alternativeKAWASHIMA, Hidenorija
dc.contributor.alternativeKAKINOKI, Kosukeja
dc.contributor.alternativeISEKI, Tatuoja
dc.contributor.alternativeUMEDA, Masaruja
dc.contributor.alternativeTANABE, Shigeruja
dc.contributor.alternativeNISHISAKA, Nobuyasuja
dc.contributor.alternativeASAKAWA, Masazumija
dc.date.accessioned2010-06-01T02:00:46Z-
dc.date.available2010-06-01T02:00:46Z-
dc.date.issued1989-07ja
dc.identifier.issn0018-1994ja
dc.identifier.urihttp://hdl.handle.net/2433/116610-
dc.description.abstract慢性糸球体腎炎36例,前立腺肥大症24例,糖尿病性腎症6例,腎盂腎炎8例,計74例を対象とし,腎糸球体濾過機能を表すとされている血中β2 microglobulin (SBMG)値と,尿細管障碍の評価に有用とされている尿中逸脱酵素・蛋白(N-Acetyl-β-D-glucosaminidase (NAG),β2 microglobulin (β2 MG),α1 microglobulin (α1 MG)測定値を比較,検討した.SBMGが高値を示すに伴ってNAG, β2 MG, β1 MGも高値を示したが,それを仔細に分析すると,糸球体濾過機能障碍に伴う尿細管機能障碍の評価としては尿中α1 MG>NAG>β2 MGの順に有用であり,かつそれら単独よりも尿中α1 MGとNAGの組合わせの方が更に有用であったja
dc.description.abstractUrinary splitting enzymes and proteins including N-acetyl-b-D-glucosanimidase (NAG), beta 2 microglobulin (beta 2MG), and alpha 1 microglobulin: (alpha 1MG), which are established to be useful in the evaluation of renal dysfunction, especially renal tubular impairment, were measured to determine the extent of renal tubular impairment in relation to the degree of glomerular dysfunction in patients with renal deterioration. In healthy volunteers, urinary NAG, alpha 1MG and beta 2MG levels were 3.5 +/- 1.4 (mean +/- SD) U/g creatinine, 2.5 +/- 2.0 mg/l and 88 +/- 75 micrograms/l, respectively. While serum beta 2MG level (SBMG; microgram/ml) was between 2.0 and 2.9, among the patients with renal dysfunction, NAG, alpha 1MG and BMG levels showed 8.6 +/- 5.5, 9.8 +/- 5.8 and 785 +/- 1,264, respectively, and further elevated to 10.1 +/- 5.0, 16.5 +/- 0.7 and 525 +/- 440, respectively with a SBMG level over 3.0. Thus glomerular function was deteriorated, urinary alpha 1MG level elevated to significantly higher with a parallel to renal dysfunction. In patients with more severe renal dysfunction, the corresponding urinary NAG and alpha 1MG levels became significantly higher. However, urinary beta 2MG level was significantly higher in patients with moderate renal dysfunction compared to healthy volunteers only when SBMG level was more than 2.0. Therefore, it was more valuable to measure urinary alpha 1MG with NAG or beta 2MG at SBMG level of less than 1.9 and to determine urinary NAG and alpha 1MG at greater than 2.0. These results indicated that the measurement of the levels of urinary splitting enzymes and proteins is valuable in the evaluation of proximal tubular impairment, even when the degree of glomerular impairment is minimal.(ABSTRACT TRUNCATED AT 250 WORDS)ja
dc.format.mimetypeapplication/pdfja
dc.language.isojpnja
dc.publisher泌尿器科紀要刊行会ja
dc.subjectEnzymuriaja
dc.subjectProteinuriaja
dc.subjectRenal glomerulo-tubular impairmentja
dc.subject.ndc494.9ja
dc.title尿中逸脱酵素・蛋白に関する研究 第2報: 糸球体炉過機能と尿中逸脱酵素・蛋白の関係についてja
dc.title.alternativeStudies of enzymuria and proteinuria: Report 2; Relationship between glomerular filtration rate and urinary enzymuria and proteinuriaja
dc.type.niitypeDepartmental Bulletin Paperja
dc.identifier.ncidAN00208315ja
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume35ja
dc.identifier.issue7ja
dc.identifier.spage1125ja
dc.identifier.epage1128ja
dc.textversionpublisherja
dc.sortkey05ja
dc.address大阪市立北市民病院泌尿器科ja
dc.address大阪市立北市民病院泌尿器科ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address.alternativethe Department of Urology, Osaka Municipal Kita Citizen's Hospitalja
dc.address.alternativethe Department of Urology, Osaka Municipal Kita Citizen's Hospitalja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativeFrcmthe Department of Urology, Osaka City University Medical Schoolja
dc.identifier.pmid2478007ja
Appears in Collections:Vol.35 No.7

Show simple item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.