前立腺癌の臨床的検討

Abstract

80例(11年間)は男性入院患者の4%, 70歳代に多く, 排尿障害を主訴とした.症状発現より受診まで6～12ヵ月が最も多く, 平均22ヵ月.Stage分離(%)A8・B10・C11・D71.高分化・中分化とも30%・低分化40%.T分類(%)T0 9・T0 4・T2・48・T3 28・T4 13.Dは低分化が占めた.治療法(%)内分泌71・放射線16・手術8・化学療法5であった.全症例で5年生存率(%)は54, Aは4年まで100%生存した.B・C・Dの5年生存率は100・88・41%で, T0は4年生存率82%・T1・T2・T3の5年生存率が100・87・30%・T4の3年生存率は7%となり, 高分化の5年生存率は50・中分化80・低分化42%であった

Eighty patients with prostatic cancer, who first visited Kyorin University School of Medicine from January 1976 through December 1986, were analyzed. Incidence of prostatic cancer was 3.9% among male inpatients. Age distribution was between 55 and 88, with an average of 72 years old. The most common symptoms were dysuria followed by pollakisuria, hematuria, lumbago and lower extremity pain. Duration from onset of symptom to examination ranged from 6 to 84 months, with an average of 22 months. Clinical stage was A in 7.5%, B in 10%, C in 11.3% and D in 71.3%. According to histological grade, well, moderately, and poorly differentiated adenocarcinomas were observed in 29.9, 29.9 and 40.2%, respectively. According to the General Rules for Clinical and Pathological Studies on Prostatic Cancer, clinical T classification were T0 in 8.7%, T1 in 3.8%, T2 in 47.5%, T3 in 27.5% and T4 in 12.5%. In the correlation between stage and grade, the largest number of poorly differentiated adenocarcinoma cases was in stage D. There was no correlation between stage and T classification. Of the 80 patients, 71.25% were treated with antiandrogen therapy, 16.25% with radiation therapy chiefly, 7.5% by surgery chiefly, and 5% with chemotherapy. Survival rate was calculated by the Kaplan-Meier method. Overall survival rate of the 80 patients was 54.4% at 5 years. Survival rate by stage were 100% in stage A at 4 years, and 100% in B, 87.5% in C and 40.5% in D at 5 years.(ABSTRACT TRUNCATED AT 250 WORDS)