膀胱頸部におけるVIP神経の役割

Abstract

前立腺肥大症9例, 膀胱頸部硬化症5例の計14例から得た組織を用いて, 免疫組織化学的手法を用いてVIP神経を検討した.膀胱頸部硬化症では染色されにくく, 前立腺肥大症により多く染色され, さらに, 両者をあわせてみると, 残尿の少ない症例に良く染色された.したがって, VIPは排尿時における膀胱頸部の開大維持に役割を持っているのではないかと考えられた

VIP-containing nerves have been considered as an inhibitory nerve of non-cholinergic, non-adrenergic action in the bladder neck. Using immunohistochemistry, VIP was stained in the bladder neck in 14 cases which involved 5 cases of bladder neck contracture in addition to 9 cases of benign prostatic hypertrophy (BPH). Consequently, the VIP immunoreactive nerve was not stained in the 4 cases of bladder neck contracture with a large quantity of residual urine which had the fibrosis of bladder neck, but in one case was stained without residual urine. In the BPH, 8 out of 9 cases were stained and they had small residual urine. It was fully stained in the cases without residual urine or with a small volume if they had it. The possible role of VIP in the bladder neck was supposed to be to maintain the bladder neck opening by the strong smooth muscle relaxation.