膀胱腫瘍におけるMalignant potentialの指標としてのABH-isoantigen CEA,BMG,Leu-M1,H抗原の併用に関する検討

Abstract

初発表在性膀胱腫瘍43例を対象に, 免疫組織化学的手法にてBGA, CEA, BMG, Leu-M1, H-Agを検索した.1)同一組織におけるBGA, CEA, BMG, Leu-M1, H-Agの染色性に関しては, 相互に明らかな関連性は認められなかった.2) BGA, CEA, Leu-M1は, それぞれ単独でmalignant potentialの指標となるうるが, その中では特にBGAの有用性が最も高かった.3) BGAを基本とするBGAとLeu-M1の併用は, BGA単独に比して, より客観的な予後予測法と考えられ, 新しい判定法を提唱した

The author performed immunohistochemical staining of blood group antigen (BGA), CEA, BMG, Leu-M1 and H-Ag on 43 patients with primary superficial bladder tumor to evaluate the malignant potential of bladder tumor. There were no obvious relationships among reactivities to BGA, CEA, BMG, Leu-M1 and H-Ag in identical tissue. Although BGA, CEA and Leu-M1 could be used individually as indicators of malignant potential, of the three, BGA was found to be most useful. Concomitant use of Leu-M1 with BGA might compensate for the disadvantages of BGA alone and make prediction of prognosis more objective. Then, a new evaluation criteria for detecting malignant potential of bladder tumor was proposed.