ダウンロード数: 372
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
35_1299.pdf | 403.59 kB | Adobe PDF | 見る/開く |
タイトル: | 腎移植患者における尿蛋白,尿FDP (fibrinogen degradation products)および尿NAG (N-acetyl-β-glucosaminidase)の検討 |
その他のタイトル: | Studies of urinary proteins, FDP (fibrinogen degradation products), and NAG (N-acetyl-beta-D-glucosaminidase) in renal transplanted patients |
著者: | 国方, 聖司 池上, 雅久 今西, 正昭 西岡, 伯 石井, 徳味 植村, 匡志 神田, 英憲 松浦, 健 秋山, 隆弘 栗田, 学 |
著者名の別形: | Kunikata, Seiji Ikegami, Masahisa Imanishi, Masaaki Nishioka, Tsukasa Ishii, Tokumi Uemura, Tadashi Kanda, Hideyori Matsuura, Takeshi Akiyama, Takahiro Kurita, Takashi |
キーワード: | Acetylglucosaminidase/urine Azathioprine/therapeutic use Cyclosporins/therapeutic use Fibrin Fibrinogen Degradation Products/urine Graft Rejection/physiology Hexosaminidases/urine Humans Immunosuppressive Agents/therapeutic use Kidney/drug effects Kidney Transplantation/physiology |
発行日: | Aug-1989 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 35 |
号: | 8 |
開始ページ: | 1299 |
終了ページ: | 1304 |
抄録: | The urinary proteins, FDP (fibrinogen degradation products), and NAG (N-acetyl-beta-D-glucosaminidase) in renal transplanted patients were studied. SDS (sodium dodecyl sulphate) electrophoresis was used for the differentiation of urinary proteins according to their molecular size. In the azathioprine-treated patients with stable renal function, most of the urinary proteins were albumin. However, the low molecular weight (LMW) proteins, which were suggestive of tubular proteins, appeared in the urine of the ciclosporin-treated patients with stable renal function. During the rejection episodes of the ciclosporin-treated patients, the fraction of LMW proteins increased. The elevation of urinary FDP and NAG index (urinary NAG/urinary Cr) were detected in association with rejection episodes. Urinary NAG index increased in proportion to the elevation of serum Cr. However, the elevation of urinary NAG index was found in some ciclosporin-treated patients with normal serum Cr. The elevation of NAG index without the elevation of urinary FDP occurred in ciclosporin nephrotoxicity. The SDS electrophoresis of urinary proteins, urinary FDP, and urinary NAG index can be useful parameters for monitoring ciclosporin nephrotoxicity. |
URI: | http://hdl.handle.net/2433/116647 |
PubMed ID: | 2816597 |
出現コレクション: | Vol.35 No.8 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。