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タイトル: | 尿路上皮癌腫瘍マーカーとしての膵分泌性トリプシン・インヒビター |
その他のタイトル: | Pancreatic secretory trypsin inhibitor in urothelial cancer |
著者: | 田代, 和也 鳥居, 伸一郎 岩室, 紳也 大石, 幸彦 長谷川, 倫男 川島, 禎男 望月, 篤 吉越, 富久夫 和田, 鉄郎 町田, 豊平 |
著者名の別形: | TASHIRO, Kazuya TORII, Shinichiro IWAMURO, Shinya OHISHI, Yukihiko HASEGAWA, Norio KAWASHIMA, Yoshio MOCHIZUKI, Atsushi YOSHIGOE, Hukuo WADA, Tetsuro MACHIDA, Toyohei |
キーワード: | Urothelial cancer Pancreatic secretory trypsin inbibitor |
発行日: | Oct-1989 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 35 |
号: | 10 |
開始ページ: | 1659 |
終了ページ: | 1663 |
抄録: | Pancreatic secretory trypsin inhibitor (PSTI) levels are known to increase in some kinds of cancer. We determined the PSTI levels in patients with urothelial cancer to evaluate its usefulness as a tumor marker. The subjects were 101 patients who had bladder cancer (n = 81) or renal pelvis and ureter cancer (n = 20). Twenty-six healthy volunteers were used as controls. PSTI was measured by an RI kit using the double antibody method, and levels above 20 ng/ml were taken as positive. Serum tissue polypeptide antigen (TPA) levels were also measured in 32 cases. None of the controls, 65% of the patients with renal pelvis and ureter cancer, and 30.9% of bladder cancer had positive levels of PSTI. The positive rate for each stage was 22.3% for Tis, Taand T1, 38.5% for T2, 73.3% for T3 and 100% for T4. The rate tended to increase with the progress of tumor infiltration. All subjects with positive readings above 30 ng/ml had progressive cancer. The usefulness of PSTI as a tumor marker was similar to that of TPA. PSTI is not a specific marker of urothelial cancer, but it showed an association with the progression of cancer. Therefore, it is considered to be a useful marker to determine postoperative metastasis, recurrence, and disease progression. |
URI: | http://hdl.handle.net/2433/116721 |
PubMed ID: | 2610172 |
出現コレクション: | Vol.35 No.10 |
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