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Title: 膀胱腫瘍における尿細胞診の臨床的検討 - 尿細胞診陽性に関与する因子の検討 -
Other Titles: Clinical study of urinary cytology in bladder tumors--analysis of factors related with positivity of urinary cytology
Authors: 田中, 国晃  KAKEN_name
高士, 宗久  KAKEN_name
佐橋, 正文  KAKEN_name
下地, 敏雄  KAKEN_name
三宅, 弘治  KAKEN_name
越川, 卓  KAKEN_name
白井, 孝夫  KAKEN_name
川島, 康平  KAKEN_name
中島, 伸夫  KAKEN_name
浜島, 信之  KAKEN_name
Author's alias: Tanaka, Kuniaki
Takashi, Munehisa
Sahashi, Masafumi
Shimoji, Toshio
Miyake, Kouji
Koshikawa, Takashi
Shirai, Takao
Kawashima, Kouhei
Nakajima, Nobuo
Hamajima, Nobuyuki
Keywords: Bladder cancer
Urinary cytology
Positive rate
Multivariate analysis
Issue Date: Jan-1990
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 36
Issue: 1
Start page: 7
End page: 11
Abstract: To clarify the clinical and pathological determinants affecting the sensitivity of urinary cytology, we reviewed cytological findings from 119 patients with bladder cancer who were initially treated between January 1982 and March 1988. Cytological specimens obtained from voided urine were stained by the Giemsa and Papanicolaou techniques, and were classified into three categories of malignant cells: positive, suspicious, and negative. Of 311 specimens examined, 114 (37%) were positive, 81 (26%) were suspicious, and the remaining 116 (37%) were negative. The overall positive rate, or sensitivity, was 50% (60 out of 119 patients). The sensitivities were 7% for patients with grade 1 tumors, 42% for grade 2 tumors, and 97% for grade 3 tumors. Univariate analysis by logistic regression analysis revealed that grade, stage, histological pattern of growth, size and number of tumors, and patient age were significantly related with the positivity of voided urinary cytology. The logistic regression model, as a multivariate analysis, demonstrated that grade was the most important determinant affecting the positive cytologic finding, followed by number of tumors with statistical significance. We conclude that the lower sensitivity in conventional urinary cytology for low-grade tumors necessitates new adjuncts, including immunocytochemistry and flow cytometry, to lower the false-negative rate.
PubMed ID: 1689930
Appears in Collections:Vol.36 No.1

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