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タイトル: | Anti-androgenの性機能におよぼす影響 - アリルエストレノールおよび酢酸クロルマジノンの二重盲検法比較試験第1報:夜間睡眠時勃起現象(NPT)測定による検討 - |
その他のタイトル: | Effects of anti-androgens on sexual function. Double-blind comparative studies on allylestrenol and chlormadinone acetate Part I: Nocturnal penile tumescence monitoring |
著者: | 熊本, 悦明 山口, 康宏 佐藤, 嘉一 丹田, 均 加藤, 修爾 毛利, 和富 門野, 雅夫 本間, 昭雄 三宅, 正文 青木, 正治 恒川, 琢司 江夏, 朝松 丸田, 浩 大堀, 勉 青木, 光 萬谷, 嘉明 鈴木, 騏一 石井, 延久 入沢, 千晶 今村, 一男 吉田, 英機 白井, 将文 高波, 真佐治 松島, 正浩 田島, 政晴 鈴木, 良二 松本, 英亜 牧, 昭夫 藤尾, 幸司 中山, 孝一 深澤, 潔 三浦, 一陽 長田, 尚夫 矢島, 通孝 片山, 喬 寺田, 為義 守殿, 貞夫 安野, 博彦 井谷, 淳 斉藤, 宗吾 今川, 章夫 前林, 浩次 荒木, 徹 高本, 均 杉山, 善朗 中村, 浩 志田, 圭三 |
著者名の別形: | Kumamoto, Yoshiaki Yamaguchi, Yasuhiro Sato, Yoshikazu Tanda, Hitoshi Kato, Shuji Mori, Kazutomi Kadono, Masao Honma, Akio Miyake, Masafumi Aoki, Masaharu Tsunekawa, Takuji Enatsu, Chosyo Maruta, Hiroshi Ohhori, Tsutomu Aoki, Hikaru Banya, Yoshiaki Suzuki, Kiichi Ishii, Nobuhisa Irisawa, Chiaki Imamura, Kazuo Yoshida, Hideki Shirai, Masafumi Takanami, Masaharu Matsushima, Masahiro Tajima, Masaharu Suzuki, Ryoji Matsumoto, Hidetsugu Maki, Akio Fujio, Kouji Nakayama, Koichi Fukazawa, Kiyoshi Miura, Kazukiyo Osada, Takao Yajima, Michitaka Katayama, Takashi Terada, Tameyoshi Kamidono, Sadao Yasuno, Hirohiko Itani, Atsushi Saito, Sogo Imagawa, Akio Maebayashi, Koji Araki, Tohru Takamoto, Hitoshi Sugiyama, Yoshio Nakamura, Kou Shida, Keizo |
キーワード: | Antiandrogen Sexual function NPT Allylestrenol Benign prostatic hypertrophy |
発行日: | Feb-1990 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 36 |
号: | 2 |
開始ページ: | 213 |
終了ページ: | 226 |
抄録: | Allylestrenol (ALE) and chlormadinone acetate (CMA) were administered to patients with prostatomegaly by the double-blind method, and the effects of these antiandrogens on their sexual function were objectively compared. Each agent was orally administered to 58 patients in a dosage of 50 mg/day for 12 consecutive weeks. For the objective evaluation of the sexual function, nocturnal penil tumescence (NPT) was measured using an erectometer. For the subjective evaluation the conventional interview method was employed. The levels of hormones relating to sexual function were also determined. A decrease in NPT was noted in both the ALE and CMA groups, but the degree of the decrease was significantly smaller in the ALE group than in the CMA group (p less than 0.001). The results of the interview, revealed a large between the two drug groups; in the CMA group, marked worsening for all items. In the determination of hormones, levels of luteinizing hormone, follicle stimulating hormone, testosterone and estradiol were decreased in both drug groups, while the prolactin level was increased in both groups. The changes in the testosterone, estradiol and prolactin levels in the CMA group were significantly dominant compared with those in the ALE group. In addition, drop-out cases due to a decrease in the sexual function numbered 7 (12.1%) in the CMA group, while there were no such drop-out cases in the ALE group; the difference in the drop-out rate was thus significant. In conclusion, ALE's effects on the sexual function were concluded to be smaller than those of CMA. |
URI: | http://hdl.handle.net/2433/116823 |
PubMed ID: | 1693037 |
出現コレクション: | Vol.36 No.2 |
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