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Title: 表在性膀胱腫瘍に対する膀胱内注入療法の臨床的検討 - Mitomycin C,Adriamycin,PeplomycinとCytosine Arabinosideの併用療法にについて -
Other Titles: Clinical study of intravesical instillation therapy of superficial bladder tumor--combination therapy of mitomycin C, adriamycin, peplomycin and cytosine arabinoside
Authors: 木下, 修隆  KAKEN_name
栃木, 宏水  KAKEN_name
柳川, 真  KAKEN_name
山川, 謙輔  KAKEN_name
桜井, 正樹  KAKEN_name
日置, 琢一  KAKEN_name
川村, 寿一  KAKEN_name
Author's alias: Kinoshita, Nobutaka
Tochigi, Hiromi
Yanagawa, Makoto
Yamakawa, Kensuke
Sakurai, Masaki
Hioki, Takuichi
Kawamura, Juichi
Keywords: Intravesical instillation
Mitomycin C
Cytosine Arabinoside
Issue Date: Mar-1990
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 36
Issue: 3
Start page: 257
End page: 263
Abstract: The effect of intravesical combination chemotherapy on superficial bladder tumors was analyzed. Seventy-two patients were treated with intravesical instillation of the following anticancer drugs. MMC group: Mitomycin C (MMC) 10 mg and cytosine arabinoside (CA) 300 mg. ADM group: Adriamycin (ADM) 30 mg and CA 300 mg. PEP group: Peplomycin (PEP) 30 mg and CA 300 mg. MAC group: MMC 10 mg, ADM 30 mg and CA 300 mg. Antitumor effects in the MMC, ADM, PEP and MAC groups were evaluated in 16, 18, 17 and 21 patients and objective response (CR + PR) of tumor was observed in 87.5%, 50.0%, 35.3% and 28.6% of these patients. The papillary tumors, small tumors and low grade tumors responded better to these intravesical chemotherapies than the non-papillary tumors, the middle grade tumors and the high grade tumors. The recurrence rate in 72 patients was 6.9, 14.6 and 26.8% within 1, 2 and 3 years. No significant difference in the recurrence rate was observed between the MMC, ADM, PEP and MAC group, but the MMC group tended to have a lower recurrence rate than the other groups. The recurrence rate for the low grade tumors and the middle grade tumors was significantly lower than that for the high grade tumors and the small tumors. The major side effect of instillation therapy with these drugs was bladder irritation which appeared in 16.7% of all the patients (78 cases). In conclusion, intravesical chemotherapy is a useful approach for controlling superficial urinary bladder tumors, especially the combination of MMC and CA.
PubMed ID: 1693807
Appears in Collections:Vol.36 No.3

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