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Title: 膀胱腫瘍の再発防止に関する研究 - UFT内服による再発防止効果 -
Other Titles: Prophylactic effect of UFT on the recurrence of bladder cancer
Authors: 内藤, 克輔  KAKEN_name
久住, 治男  KAKEN_name
酒井, 晃  KAKEN_name
中村, 武夫  KAKEN_name
神田, 静人  KAKEN_name
美川, 郁夫  KAKEN_name
江尻, 進  KAKEN_name
宮城, 徹三郎  KAKEN_name
勝見, 哲郎  KAKEN_name
北川, 清隆  KAKEN_name
奥村, 良二  KAKEN_name
川口, 光平  KAKEN_name
折戸, 松男  KAKEN_name
亀田, 健一  KAKEN_name
庄田, 良中  KAKEN_name
島田, 宏一郎  KAKEN_name
中島, 慎一  KAKEN_name
南後, 千秋  KAKEN_name
宮崎, 公臣  KAKEN_name
小坂, 哲志  KAKEN_name
橋本, 和夫  KAKEN_name
Author's alias: Naito, Katsusuke
Hisazumi, Haruo
Saka, Akira
Nakamura, Takeo
Kanda, Shizuto
Mikawa, Ikuo
Ejiri, Susumu
Miyagi, Tetsusaburou
Katsumi, Tetsurou
Kitagawa, Kiyotaka
Okumura, Ryouji
Kawaguchi, Kouhei
Orito, Matsuo
Kameda, Kenichi
Shoda, Ryouchyu
Shimada, Kouichirou
Nakajima, Shinichi
Nango, Chiaki
Miyazaki, Kimiomi
Kosaka, Satoshi
Hashimoto, Kazuo
Keywords: Bladder cancer
Randomized study
Issue Date: Apr-1990
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 36
Issue: 4
Start page: 487
End page: 494
Abstract: To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were given UFT and 55 were followed up without any medication. The non-recurrence rate in the group treated with UFT was 62.8% after 1 year and 36.3% after 2 years of follow up, and that of the control group was 45.7% and 39.5%, respectively. The rate of non-recurrence in the UFT group was significantly higher (p less than 0.05) than that of the control group during the period of follow up for 2 years. The incidence of side effects was 6.8% in UFT patients. These results indicate the clinical usefulness of prophylactic administration of UFT for bladder cancer patients.
PubMed ID: 2116083
Appears in Collections:Vol.36 No.4

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