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タイトル: | キロサイドを含む膀胱内注入療法: 再発予防効果について |
その他のタイトル: | Intravesical instillation chemotherapy of anticancer agents including cylocide: studies of prophylactic effects on the recurrence |
著者: | 安本, 亮二 浅川, 正純 吉原, 秀高 坂本, 亘 井関, 達男 仲谷, 達也 和田, 誠次 岸本, 武利 前川, 正信 西尾, 正一 堀井, 明範 田中, 寛 西島, 高明 川喜多, 順二 早原, 信行 柏原, 昇 大山, 武司 山口, 哲男 辻田, 正昭 山本, 啓介 松村, 俊宏 森川, 洋二 梅田, 優 鶴崎, 清之 前川, たかし 結城, 清之 |
著者名の別形: | Yasumoto, Ryoji Asakawa, Masazumi Yoshihara, Hidetaka Sakamoto, Wataru Iseki, Tatsuo Nakatani, Tatsuya Wada, Seiji Kishimoto, Taketoshi Maekawa, Masanobu Nishio, Shoichi Horii, Akinori Tanaka, Hiroshi Nishijima, Takaaki Kawakita, Junji Hayahara, Nobuyuki Kashiwara, Noboru Oyama, Takeshi Yamaguchi, Tetsuo Tsujita, Masaaki Yamamoto, Keisuke Matsumura, Toshihiro Morikawa, Yoji Umeda, Masaru Tsurusaki, Kiyoyuki Maekawa, Takashi Yuuki, Kiyoyuki |
キーワード: | Bladder tumor Combined intravesical chemotherapy Cylocide Mitomycin C Adriamycin |
発行日: | Apr-1990 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 36 |
号: | 4 |
開始ページ: | 407 |
終了ページ: | 413 |
抄録: | We studied the efficacy of intravesical instillation chemotherapy of anticancer agents including cylocide (CA) in the prevention of recurrence of bladder tumor after surgery. Totally 60 patients with superficial bladder tumor were enrolled into the study. The patients were randomly assigned to either one of three groups: CA 300 mg alone, CA 200 mg + mitomycin C (MMC) 10 mg, and CA 180 mg + adriamycin (ADM) 20 mg. These drugs were initially instilled once a day for one week, and then once a month until 2 years after surgery. Thereafter, the patients were followed up without instillation. The cumulative non-recurrence rates in the CA group was 76.5, 60.0 and 60.0% at 1, 2 and 3 years after the removal of bladder tumor, respectively, while that in the CA + MMC treated group 90.9, 75.3, and 75.3% and that in the CA + ADM treated group, 95.1, 82.9 and 82.9%, respectively. The recurrence rate in the CA, CA + MMC and CA + ADM treated group was 35.3, 27.3 and 19.0%, respectively, the recurrence indices 1.84, 1.07 and 0.74, and the mean times between recurrence 10.8, 16.5 and 18.0 months, respectively. Side effects were noted in 3 of the 17 cases (17.6%) in the CA group, in 3 of the 22 cases (13.6%) in the CA + MMC group and in 3 of the 21 cases (14.3%) in the CA + ADM treated group. These data show that intravesical CA instillation in combination with MMC or ADM is more effective for the prevention of recurrence than that of CA alone. |
URI: | http://hdl.handle.net/2433/116885 |
PubMed ID: | 2116082 |
出現コレクション: | Vol.36 No.4 |
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