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タイトル: | ヌードマウス可移植性ヒト腎細胞癌に対するインターフェロンα(HLBI)とUFT,5-Fuの併用効果 |
その他のタイトル: | Combination chemotherapy of human renal cell carcinoma in athymic nude mice with human lymphoblastoid interferon (HLBI) and UFT, 5-Fu |
著者: | 山田, 芳彰 村松, 直 本多, 靖明 深津, 英捷 瀬川, 昭夫 平田, 紀光 千田, 八朗 |
著者名の別形: | Yamada, Yoshiaki Muramatsu, Tadashi Honda, Nobuaki Fukatsu, Hidetoshi Segawa, Akio Hirata, Norimitsu Senda, Hachiro |
キーワード: | Nude mouse Renal cell carcinoma Combination chemotherapy UFT HLBI |
発行日: | May-1990 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 36 |
号: | 5 |
開始ページ: | 527 |
終了ページ: | 534 |
抄録: | The effectiveness of interferon alpha (HLBI) for nude mouse transplantable human renal cell carcinoma 72nd general meeting, in combination with UFT and 5-Fu, was examined using, 1 x 10(7) IU/kg, 2 x 10(7) IU/kg HLBI; 25 mg/kg 5-Fu; and 10 mg/kg, 20 mg/kg UFT, administered for 10 consecutive days. The ratio of relative mean tumor weight of treated group to control group was under 42% for the combination of 25 mg/kg (I.P.) 5-Fu, 20 mg/kg UFT, and HLBI and the effect was particularly clear for the combination with 2 x 10(7) IU/kg which indicated a grade IIA histologic classification. In comparison with the control groups only UFT (20 mg/kg) and HLBI (2 x 10(7) IU/kg) showed significant inhibition when administered alone. Although none of the drugs had an inhibitory effect when administered alone, in combined use they showed a strong antitumor effect which was more than synergistic. Orally administered 5-Fu showed a statistically significant difference only in the combination with 2 x 10(7) IU/kg HLBI. Furthermore, the concentration of 5-Fu in the tumor tissue was not affected by the route of administration or drug combination, whereas that in the serum was below the limit of detection in the intraperitoneally administered cases, 0.0096 +/- 0.0079 microgram/ml, lower than the value for orally administered cases. The 5-Fu concentration was 0.026 +/- 0.012 microgram/ml for orally administered UFT which was significantly higher than the value obtained for orally administered 5-Fu. Thus, combination therapy of HLBI and UFT for renal cell carcinoma is expected to be clinically useful. |
URI: | http://hdl.handle.net/2433/116911 |
PubMed ID: | 2119093 |
出現コレクション: | Vol.36 No.5 |
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