慢性前立腺炎と前立腺炎様症候群の臨床的研究 第4報: 前立腺炎難治症例に対する漢方療法

Abstract

西洋医学治療の結果, 難治・再発した慢性非細菌性前立腺炎と前立腺炎様症候群の症例に対し漢方療法を試みた.1)漢方療法の臨床効果は, 慢性非細菌性前立腺炎61例では著効率21.3%, 臨床的有効率67.2%であり, 前立腺炎様症候群82例では著効率19.5%, 臨床的有効率52.4%であった.2)漢方単独療法と西洋薬併用治療群の効果を比較すると, 前立腺炎様症候群では両群間に差はないが, 慢性非細菌性前立腺炎では漢方単独群より抗菌剤併用群の方が効果が優れていた(p<0.1).3)慢性非細菌性前立腺炎での併用抗菌剤の効果では, new-quinolon系薬剤がST合剤やtetracycline系薬剤より良好であった.4)使用漢方薬の臨床効果を検討し, 両病型ともに桂枝茯苓丸と四物湯の効果が良好であった.5)漢方療法での副作用発現率は9例6.3%であり, 桂枝茯苓丸の投与例に多かった

Kampo treatment was attempted in cases of chronic nonbacterial prostatitis and prostatitis-like syndrome which was intractable or recurred when treated with western medicine. The clinical effects of Kampo treatment were excellent in 21.3% with an efficacy rate of 67.2% for the cases with chronic non-bacterial prostatitis, and excellent in 19.5% with an efficacy rate of 52.4% in the cases with prostatitis-like syndrome. When the clinical effects were compared with those of western therapy performed in the cases which had recurrence, Kampo treatment showed more excellent effects (p less than 0.1) for both types of disease, and the treatment with Chinese medicine was suggested useful. In a comparison of the effects between the cases given only Kampo treatment and those given both Kampo treatment and western treatment using anti-inflammatory agents, no difference was seen in the cases with the prostatitis-like syndrome, but in the cases with chronic non-bacterial prostatitis, the effects were better in the concomitant treatment group than in the group given only Kampo treatment (p less than 0.1). The response to the Kampo treatment differed depending on the type of disease. Among the antibacterial agents used concomitantly in the cases of chronic non-bacterial prostatitis, new-quinolones showed better results than ST compounds or tetracyclines, but no statistically significant differences were seen among the drugs. Of the Kampo drugs used, Keisibukuryogan and Simotuto showed high clinical usefulness in both types of disease and there was no statistically significant difference among the other drugs. The incidence rate of side effects (Goji) due to Kampo treatment was 6.3% and was higher in patients administered Keisibukuryogan.