膀胱癌に対するCis DDPと放射線照射の併用療法

Abstract

High grade, high stageあるいは根治手術後の膀胱癌20例に対しcis-diaminedichloroplatinum (CDDP)と放射線照射の併用療法を施行した.この内再発例は4例で効果判定可能な3例はすべてcomplete response (CR)であった.初発例は16例で効果判定可能な14例中10例は6ヵ月を経過して全例, 再発を認めず社会復帰している.副作用はいずれも許容範囲内の程度のものであった

Combination therapy consisting of cis-diamine-dichloroplatinum (CDDP) and radiotherapy was used to treat bladder cancer. The subjects were 20 patients with bladder cancer we experienced since September, 1986. They were between 33 and 83 years old and consisted of 13 males and 7 females. Among the histotypes and grades, there were 3 cases of G2, 7 of G2-G3 and 10 of G3 metastatic epithelial carcinoma. The classification of primary tumors was T2 in six cases, T3a in 12 cases and T4 in two cases. In 12 cases where the bladder was preserved, this therapy was performed after TUR biopsy or TUR, and the effects were evaluated after observation periods of 5-17 months. Side effects caused by CDDP were anorexia in 15 cases, nausea and vomiting in 10 cases, leukopenia in 10 cases and thrombocytopenia in four cases. Those caused by the radiotherapy were diarrhea in seven cases and skin disorders in six cases. All of these side effects were mild and the patients recovered spontaneously.