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Title: STDとしての男子尿道炎・子宮頸管炎の疫学的・治療学的研究 - NY-198(Lomefloxacin)による検討 -
Other Titles: Epidemiological and therapeutic study on urethritis of male and cervicitis from viewpoint of STD--a study using NY-198. Sapporo Clinical Research Group for STD
Authors: 熊本, 悦明  KAKEN_name
広瀬, 崇興  KAKEN_name
林, 謙治  KAKEN_name
郷路, 勉  KAKEN_name
児玉, 直彦  KAKEN_name
宮岸, 武弘  KAKEN_name
上野, 了  KAKEN_name
毛利, 和弘  KAKEN_name
阿部, 清孝  KAKEN_name
Author's alias: Kumamoto, Yoshiaki
Hirose, Takaoki
Hayashi, Kenji
Gohro, Tsutomu
Kodama, Naohiko
Miyagishi, Takehiro
Ueno, Toru
Mohri, Kazuhiro
Abe, Kiyotaka
Keywords: Non-gonococcal infection
Male urethritis
Issue Date: Aug-1990
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 36
Issue: 8
Start page: 979
End page: 987
Abstract: Urethritis in males and cervicitis in females, which were sexually transmitted diseases, were treated with NY-198, a new quinolone antibiotic, and its efficacy was studied. Seventeen male patients with gonorrheal urethritis were administered a single 300 mg dose of NY-198. The efficacy rate on the 3rd day after administration was 100%, but it was 85.7% on the 7th day due to recurrence in 1 patient. The results of treatment of non-gonorrheal infections were as follow. In this treatment, NY-198 was administered in a daily dose of 600 mg in 3 divided doses for 14 consecutive days. In the treatment of chlamydial urethritis of males, the efficacy rate in 26 patients was 84.6% on the 7th day and 84.0% on the 14th day in 25 patients. In the treatment of chlamydial cervicitis, the efficacy rate was 100% on both the 7th (3/3) and 14th (6/6) days. In the treatment of non-gonorrheal and non-chlamydial cervicitis, the efficacy rate was 100% on the 7th day (1/1) and 50% (1/2) on 14th day. The efficacy rate in all 40 males with non-gonorrheal urethritis was 85.0% on the 7th day and 88.9% for 36 patients on the 14th day, while that in all 4 females with cervicitis was 100% on the 7th day and 87.5% on the 14th day. No side effects were seen in any of the patients. Overall, NY-198 had an efficacy rate of 80% in the treatment of chlamydial infections. NY-198 was found to be a useful drug which is efficacious in the treatment of all STD-related microbes such as gonococci and chlamydia.
PubMed ID: 2122659
Appears in Collections:Vol.36 No.8

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