偏側閉塞腎尿中へのLatamoxef移行濃度に関する臨床的検討

Abstract

1) 18症例の閉塞腎尿, 対側正常腎尿, 血清中のLMOX濃度を測定した(尿管結石症12, 先天性水腎症3, 腫瘍による閉塞3).2) LMOX尿中排出濃度の予想は, DMSA腎摂取率, 腎エコーが有効であり, DMSA腎摂取率が3%以下, 腎エコーで最大腎実質厚10 mm以下の水腎尿中LMOX濃度は10 μg/ml以下であった.IVP所見によるLMOX尿中濃度の予測は不可能であった

Urinary LMOX concentration was studied in 18 patients with unilateral ureteral obstruction. The concentration of LMOX in the urine from the mild obstructed kidney was 124 to 2, 140 micrograms/ml and 10 micrograms/ml in the severely obstructed ones. The difference was probably due to the intensity and the duration of the obstruction. The patient with 99mTc-DMSA renal uptake of less than 3% also had a urinary LMOX concentration of less than 7 micrograms/ml. The above results seem to show that 7 micrograms/ml in urinary LMOX concentration is a significant figure for treatment of UTI. 99mTc-DMSA renal uptake and renal echogram were used to estimate the excretion rate of antibiotics into the urine.