尿路上皮癌に対するMethotrexate投与時の血中濃度推移について

Abstract

1) MTX 300 mg/bodyを2時間にて点滴静注した時の血中濃度は, 投与終了時には10-5M/L, 6時間後には10-6M/L, 24時間後には10-7M/Lのレベルであった.2) MTXの血中濃度は投与終了6時間後, 24時間後においては, クレアチニンクリアランスと負のよい相関を認めた.3)コック回腸膀胱からのMTXの再吸収は少ない

The plasma methotrexate (MTX) concentration was measured during 50 courses of chemotherapy on 26 urothelial cancer patients. A dose of 300 mg/body MTX was infused within 2 hours and plasma concentrations were measured at the scheduled times. Plasma level at the end of infusion was (2.3 +/- 0.8) x 10(-5) M/L, (2.9 +/- 1.9) x 10(-5) M/L at the 6th-hour, and (1.9 +/- 1.8) x 10(-7) M/L at the 24th-hour after the infusion. The plasma MTX concentration values were inversely correlated with creatinin clearance. In 6 cases of Kock pouch bladder, clean intermittent self catheterization of urine caused no meaningful increase of MTX.