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タイトル: | 尿中酵素Glycyl-prolyl dipeptidyl aminopeptidaseの泌尿器科領域における測定意義 |
その他のタイトル: | Clinical evaluation of urinary glycyl-prolyl dipeptidyl aminopeptidase in patients with urological disease |
著者: | 北村, 康男 渡辺, 学 小松原, 秀一 坂田, 安之輔 |
著者名の別形: | Kitamura, Yasuo Watanabe, Manabu Komatsubara, Shuichi Sakata, Yasunosuke |
キーワード: | Glycyl-prol yl dipeptidyl aminopeptidase N-acetyl-j9-D-glucosaminidase. Alanine amino peptidase Urological disease |
発行日: | Dec-1990 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 36 |
号: | 12 |
開始ページ: | 1391 |
終了ページ: | 1396 |
抄録: | Urinary glycyl-prolyl dipeptidyl aminopeptidase (GP-DAP) activity was measured in 18 healthy adults and 252 patients with urological diseases. The GP-DAP activity was significantly higher in patients with prostatic cancer, bladder cancer or renal cancer and also in patients with acute prostatitis or pyelonephritis than in healthy adults. GP-DAP activity was also studied during anticancerous chemotherapy and proved to be a sensitive parameter for renal damage as are urinary N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase, beta 2-microglobulin, alpha 1-microglobulin, and albumin. The analysis of tissue activities suggested that GP-DAP was located not only in the renal parenchyma but also in the prostate and seminal vesicles. |
URI: | http://hdl.handle.net/2433/117077 |
PubMed ID: | 1981655 |
出現コレクション: | Vol.36 No.12 |
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