移行上皮癌(TCC)におけるトランスフェリンリセプター(TR)の発現についての検討

Abstract

膀胱癌に対し膀胱全摘術あるいは経尿道的膀胱腫瘍切除術を受けた38例・腎盂腫瘍に対し腎尿管全摘術を受けた6例・尿管腫瘍に対し腎尿管全摘術あるいは尿管部分切除術を受けた7例のTCC 51例を対象(平均67.9歳)とした.51例中48例にTRの発現がみられ, 高いグレードや浸潤度を示す腫瘍でその発現が高度であった.経尿道的切除を行った症例では初発例より再発例の腫瘍で陽性細胞数が多くみられた

We examined the expression of transferrin receptor (TR) in transitional cell cancer (TCC) immunohistologically, to clarify its implication in tumor malignancy. Forty eight out of 51 tumors expressed TR while TR was not detected on the normal transitional epithelium of renal pelvis, ureter and urinary bladder. In general, a higher grade and more invasive TCC expressed TR more frequently and more intensely. Furthermore, recurrent tumors treated with transurethral resection significantly more frequently expressed TR than the initial tumor. These results indicate that the detection of TR on the tumor cells is useful for estimating the degree of their malignancy.