群馬県およびその近郊における前立腺癌患者の臨床統計的観察 : 1985-89年について

Abstract

1985～89年の5年間に未治療の状態で発見された前立腺癌は730例であった.平均年齢は74.0歳, 来院時主訴は排尿障害が最も多く, 74.5%, 以下頻尿, 肉眼的血尿, 排尿時痛, 癌性疼痛の順であった.症状発現から初診まで1ヵ月以内38.2%と多く, 1年以上も22.9%であった.病期Dが45.7%と多く, 以下B, C, Aの順であった.分化度では中分化48.2%, 高分化, 低分化が約25%ずつであった.転移は骨が82.9%, その中でも腰椎55.2%, 以下肋骨, 腸骨, 胸椎, 坐骨の順であった.PAP, ALPは病期の進行と共に有意に(P<0.01)上昇例が増した.初期治療としてホルモン療法が82.1%, LH-RH analogueは39.2%であった

Prostatic cancer is one of the most common malignant tumors in the field of urology. The number of patients is increasing rapidly and its importance as a mortal disease is gathering attention. In 1985, we organized a registration system for prostatic cancer patients found in and around Gunma prefecture. In this study, we analyzed the clinical characteristics of the 730 patients registered from 1985 to 1989. The results were as follows. Mean age was 74.0 years old and the number of the patients was the greatest in the eighth decade. Voiding disturbance was the most common chief complaint, followed by pollakisuria, gross hematuria and miction pain. Stage and grade distribution were as follows. Stage A 16.2%, B 21.1%, C 17.0%, D 45.7%, well differentiated 27.4%, moderately differentiated 48.2% and poorly differentiated 24.5%, respectively. A statistically significant relationship between stage and grade was observed. Bone was the most common metastatic site. The highest incidence of bone metastasis was in lumbar vertebra, followed by ribs, ilium, thoracic vertebra and ischium. The value of PAP, ALP and ESR tended to be higher in high stage patients, and that of Hb was lower. Fifty two patients were detected by mass screening. Most of these patients were in an early stage. Most of the patients were treated by hormonal therapy. LH-RH agonists constituted 39.2% of the cases given hormonal therapy.