多変量解析による前立腺癌の予後因子の検討

Abstract

1)単変量解析では, score値, stage, T分類, M分類, 腫瘍マーカー, 治療法が予後に重要であった.2)多変量解析ではscore値, M分類, AIP値が予後に重要であった.特にGleason分類は最も予後に影響しており, T分類, stage ACP PAPは予後因子とはならなかった.3) 3年目の予後ではscore値以外に転移の有無, 5年目の予後では年齢が重要な因子であった

A multivariate statistical analysis of 9 potential prognostic factors was made, using data gathered on 107 patients admitted between 1975 and 1987. After each variable was assessed separately for its prognostic importance by means of univariate analysis, a multivariate analysis using Cox's proportional hazards regression model and multivariate logistic model was done. These tests identified Gleason's score as the most important factor for all patients followed by M category and alkaline phosphatase (ALP), while Gleason's score alkaline phosphatase and age at diagnosis were most important for stage D patients. For short-term survival, the significant prognostic factors were Gleason's score and M category while for long term survival they were Gleason's score and age. T. category, stage, acid phosphatase, prostatic acid phosphatase, and treatment were found to be significantly related to survival time when examined individually; they were not found to be significant in the multivariate analysis.