浸潤性膀胱癌に対するM-VAC併用療法の検討

Abstract

1989年から2年間に加療した転移病巣を有さない浸潤性膀胱癌12例を対象とした.1) M-VAC併用療法により, 画像診断上, 全例に改善を認めたほか, 6例にDown stage, 6例にDown gradeを認めた.2)副作用は食欲低下, 悪心, 白血球減少を全例に, 脱毛, 嘔吐, 血小板減少を高頻度に認めたが, 重篤なものはなく, いずれも一過性であった

We carried out combined M-VAC therapy in 12 patients with invasive bladder cancer without metastatic foci, and studied mainly the pathohistological findings and side effects before and after chemotherapy. There were 9 male cases and 3 female cases who were between 53 and 76 years old, and 66 years old on the average. After admission, 1 or 2 courses of M-VAC therapy were performed after confirmation of the pathological tissues by transurethral resection of bladder tumor (TUR-BT), and then total cystectomy (in 6 cases) or TUR-BT (in 6 cases) was conducted after 15 days on the average. According to the combined M-VAC therapy, down-stage was noted in 6 cases (50%) and down-grade in 6 cases (50%). Side effects such as anorexia, nausea and leukopenia were noted in all cases, and depilation, vomiting and thrombopenia were frequently noted. However, all these cases were transient without any serious trouble. The usefulness of the combined M-VAC therapy in invasive bladder cancer was proven, and the possibility of elevating the therapeutic response by surgery with lesser invasion was suggested.