浸潤性膀胱癌に対する膀胱保存的治療の現況

Abstract

浸潤性膀胱癌11例を対象とした.治療前, T2が5例, T3が3例, T4が3例, TCC grade 2が8例, TCC grade 3が2例, TCC grade 3+anaplastic carcinomaが1例であった.8例では心疾患をはじめとする合併症がみられた.前治療としてradiationやTUR, 化学療法などを受けていた.HPC-adriamycin, radiationなどを併用してハイパーサーミアをおこなったところ, CRが4例, PRが4例, NCが2例, PDが1例という成績がえられた.PRの4例中,

During the 3 years from 1987 to 1990, we gave hyperthermia to 11 of the patients who visited our department for the treatment of invasive bladder cancer. Results and prognosis are reported. Stage and grade of the cancer before the treatment in 11 cases were T2 in 5 cases, T3 in 3 cases, T4 in 3 cases, transitional cell carcinoma (TCC) grade 2 in 8 cases, TCC grade 3 in 2 cases, and TCC grade 3 + anaplastic carcinoma in 1 case. Complications were observed in 8 of the 11 cases, such as severe heart disease and others. Pretreatment of radiation therapy, transurethral resection or chemotherapy was given in all cases. Hyperthermia was performed combined with hydroxypropyl cellulose-(HPC)-adriamycin, or radiation therapy, and the following results were obtained: complete response (CR) in 4 cases, partial response (PR) in 4 cases, no change (NC) in 2 cases and progressive disease (PD) in 1 case. Among 4 cases of PR, total cystectomy was performed in 3 cases. These 3 cases and the 4 cases of CR are alive now, but the other 4 patients died.