Sarcomatoid carcinoma of the bladder: a case report

Abstract

頻尿を訴えた膀胱肉腫様癌の78歳女で, 膀胱全摘除術後25ヵ月の現在, 再発所見はなく健在である.病理組織学的には大部分が紡錘形の脱分化した腫瘍細胞により構成され, 一部に上皮の特徴を有する分化した腫瘍細胞が認められ, 後者は免疫組織化学的にepithelial membrane antigenが陽性であった.又, 腫瘍の近傍の粘膜には上皮内癌が随伴していた

We reported a case of sarcomatoid carcinoma of the bladder in a 78-year-old woman presenting with pollakisuria. She has remained well without any evidence of recurrence for 25 months after radical cystectomy. Microscopic examination revealed a composition almost exclusively of spindle and dedifferentiated cells, accompanied by only a few cells retaining epithelial features of differentiation. The latter cells were immunohistochemically positive for epithelial membrane antigen (EMA). A concomitant carcinoma in situ was present in the adjacent mucosa. Immunohistochemical exploration with EMA proved useful for reinforcing the conventional histological diagnosis.