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| 38_305.pdf | 376.47 kB | Adobe PDF | 見る/開く |
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| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | 高橋, 修 | ja |
| dc.contributor.author | 今井, 強一 | ja |
| dc.contributor.author | 渡辺, 恵子 | ja |
| dc.contributor.author | 中沢, 康夫 | ja |
| dc.contributor.author | 中田, 誠司 | ja |
| dc.contributor.author | 栗田, 誠 | ja |
| dc.contributor.author | 斉藤, 佳隆 | ja |
| dc.contributor.author | 久保田, 裕 | ja |
| dc.contributor.author | 山中, 英寿 | ja |
| dc.contributor.alternative | Takahashi, Osamu | en |
| dc.contributor.alternative | Imai, Kyoichi | en |
| dc.contributor.alternative | Watanabe, Keiko | en |
| dc.contributor.alternative | Nakazawa, Yasuo | en |
| dc.contributor.alternative | Nakata, Seizi | en |
| dc.contributor.alternative | Kurita, Makoto | en |
| dc.contributor.alternative | Saito, Yoshitaka | en |
| dc.contributor.alternative | Kubota, Hiroshi | en |
| dc.contributor.alternative | Yamanaka, Hidetoshi | en |
| dc.date.accessioned | 2010-06-01T02:42:33Z | - |
| dc.date.available | 2010-06-01T02:42:33Z | - |
| dc.date.issued | 1992-03 | - |
| dc.identifier.issn | 0018-1994 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/117504 | - |
| dc.description.abstract | 新たに開発された非ステロイド系5α-reductase阻害剤, ONO-3805のラット副性器への効果をchlormadione acetate (CMA)および非ステロイド系抗アンドロゲン剤flutamide (FLU)のそれと比較した.ONO-3805は副性器重量低下についてCMAと同等の効果を示した.さらに, 本剤は血清テストステロン・レベルに影響を与えることはなかったが, CMAおよびFLUはこれを有意に変動させた | ja |
| dc.description.abstract | The effects of sodium-4-[2-(2, 3-dimethyl-4-[1-(4-isobutylphenyl) ethoxy]benzolamino)phenoxy]butyrate (ONO-3805), newly developed as a non-steroidal 5 alpha-reductase inhibitor, on rat accessory sex organs was compared with chlormadinone acetate (CMA) and non-steroidal antiandrogen, flutamide (FLU). ONO-3805 demonstrated excellent antiandrogenic activity which was similar to that of CMA in reducing the accessory sex organ weight. Moreover this agent did not show any significant effects on the serum testosterone level, but CMA and FLU changed it significantly. We previously reported the androgenic activity of antiandrogen (CMA, FLU, AA560, cyproterone acetate, medroxy progesterone, estrogen), but ONO-3805 is free of androgenic activity. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | jpn | - |
| dc.publisher | 泌尿器科紀要刊行会 | ja |
| dc.subject | 5a-reductase inhibitor | en |
| dc.subject | prostate | en |
| dc.subject | Antiandrogen | en |
| dc.subject | Accessory sex organ | en |
| dc.subject.ndc | 494.9 | - |
| dc.title | Sodium-4-〔2-{2,3-dimethyl-4-〔1-(4-isobutylphenyl)ethoxy〕benzoylamino}phenoxy〕butyrate (ONO-3805)のラット副性器への効果 | ja |
| dc.title.alternative | The effect of sodium-4-[2-(2, 3-dimethyl-4-[1-(4- isobutylphenyl)ethoxy]benzolamino)phenoxy] butyrate (ONO-3805) and antiandrogenic agents on the rat accessory sex organs | en |
| dc.type | departmental bulletin paper | - |
| dc.type.niitype | Departmental Bulletin Paper | - |
| dc.identifier.ncid | AN00208315 | - |
| dc.identifier.jtitle | 泌尿器科紀要 | ja |
| dc.identifier.volume | 38 | - |
| dc.identifier.issue | 3 | - |
| dc.identifier.spage | 305 | - |
| dc.identifier.epage | 310 | - |
| dc.textversion | publisher | - |
| dc.sortkey | 07 | - |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address | 群馬大学医学部泌尿器科学教室 | ja |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.address.alternative | the Department of Urology, Gunma University, School of Medicine | en |
| dc.identifier.pmid | 1381863 | - |
| dcterms.accessRights | open access | - |
| dc.identifier.pissn | 0018-1994 | - |
| dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
| dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
| 出現コレクション: | Vol.38 No.3 | |
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