尿路・性器感染症に対するLevofloxacin (DR-3355)の臨床的検討 : 主として慢性前立腺炎に対する有用性

Abstract

OFLXの一方の光学異性体であるlevofloxacinを尿路・性器感染症に1日300 mgまたは400 mgを平均12.0±0.5日間投与した.1)慢性複雑性尿路感染症(C-UTI):P. aeruginosaとP. stutzeriの2例に投与していずれも有効な成績をえた.2)慢性前立腺炎:i) 200 mg投与後, 1時間のPFの濃度は1.02±0.46 μg/ml (n=5)で, 対血清比は0.47±0.10であった.ii)慢性細菌性:7例中7例に除菌効果を認めた.iii)慢性非細菌性:21例中14例, 66.7%の有効率であった.3)慢性精巣上体炎:非クラミジア性の3例に治療を行い, 10～14日でいずれも有効であった.4)安全性:33例中1例に食欲不振, ふらふら感を認めたが中止後正常に復した.臨床検査値では, GOTとGPTの軽度一過性上昇を2例でみた

The clinical usefulness of levofloxacin, an optical active isomer of ofloxacin, was investigated on uro-genital infections. Patients who were treated with the drug included 2 with complicated urinary tract infections (UTI), 29 with chronic prostatitis and 3 with chronic non-chlamydial epididymitis. Levofloxacin was given to each patient at a dose of 300 mg or 400 mg a day for 7-14 days (average 12.0 +/- 0.5 days). In 2 cases of chronic UTI, infected by P. aeruginosa in one case and P. stutzeri in another case, the isolates were eradicated, and the clinical efficacy was moderate or excellent. For evaluating the effectiveness on chronic prostatitis, the patients were divided into 2 groups; group I (G-I) was chronic bacterial (number of isolates including GNR or E. faecalis, greater than or equal to 10(4) ml) and group II (G-II) was chronic non-bacterial prostatitis (number of isolates including GPC less than or equal to 10(3)/ml). A complete bacteriological response was obtained in all 7 cases, classified in G-I, but in 20 of the 27 isolates, (74.1%) in G-II. In 3 cases of chronic non-chlamydial epididymitis, the response was moderate. In safety profile, there were slight elevations in the laboratory values of glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) in one case, and that of GOT in another case. As for side effects, a 69-year-old male complained of dizziness, and anorexia after 10 days on the drug, but recovered 2 days after discontinuance of the drug.