Access count of this item: 284

Files in This Item:
File Description SizeFormat 
38_857.pdf900.91 kBAdobe PDFView/Open
Full metadata record
DC FieldValueLanguage
dc.contributor.author朴, 英哲ja
dc.contributor.author西岡, 伯ja
dc.contributor.author栗田, 孝ja
dc.contributor.author永井, 信夫ja
dc.contributor.author片岡, 喜代徳ja
dc.contributor.author新井, 豊ja
dc.contributor.author友吉, 唯夫ja
dc.contributor.author林田, 英資ja
dc.contributor.author井上, 均ja
dc.contributor.author北川, 慶幸ja
dc.contributor.author宮崎, 重ja
dc.contributor.author長谷川, 史明ja
dc.contributor.author出村, 愰ja
dc.contributor.author安本, 亮二ja
dc.contributor.author吉原, 秀高ja
dc.contributor.author前川, 正信ja
dc.contributor.author田中, 寛ja
dc.contributor.author川村, 正喜ja
dc.contributor.author井原, 英有ja
dc.contributor.author有馬, 正明ja
dc.contributor.author生駒, 文彦ja
dc.contributor.author黒田, 治朗ja
dc.contributor.author安野, 博彦ja
dc.contributor.author宮崎, 治郎ja
dc.contributor.author守殿, 貞夫ja
dc.contributor.author広岡, 九兵衛ja
dc.contributor.author梅津, 敬一ja
dc.contributor.alternativePark, Young-Cholja
dc.contributor.alternativeNishioka, Tsukasaja
dc.contributor.alternativeKurita, Takashija
dc.contributor.alternativeNagai, Nobuoja
dc.contributor.alternativeKataoka, Kiyonorija
dc.contributor.alternativeArai, Yutakaja
dc.contributor.alternativeTomoyoshi, Tadaoja
dc.contributor.alternativeHayashida, Hidesukeja
dc.contributor.alternativeInoue, Hitoshija
dc.contributor.alternativeKitagawa, Yoshiyukija
dc.contributor.alternativeMiyazaki, Shigeruja
dc.contributor.alternativeHasegawa, Fumiakija
dc.contributor.alternativeDemura, Akiraja
dc.contributor.alternativeYasumoto, Ryojija
dc.contributor.alternativeYoshihara, Hidetakaja
dc.contributor.alternativeMaekawa, Masanobuja
dc.contributor.alternativeTanaka, Hiroshija
dc.contributor.alternativeKawamura, Masakija
dc.contributor.alternativeIhara, Hidearija
dc.contributor.alternativeArima, Masaakija
dc.contributor.alternativeIkoma, Fumihikoja
dc.contributor.alternativeKuroda, Jirouja
dc.contributor.alternativeYasuno, Hirohikoja
dc.contributor.alternativeMiyazaki, Jirouja
dc.contributor.alternativeKamidono, Sadaoja
dc.contributor.alternativeHirooka, Kyubeija
dc.contributor.alternativeUmezu, Keiichija
dc.date.accessioned2010-06-01T02:48:28Z-
dc.date.available2010-06-01T02:48:28Z-
dc.date.issued1992-07ja
dc.identifier.issn0018-1994ja
dc.identifier.urihttp://hdl.handle.net/2433/117591-
dc.description.abstract1)テラゾシンの前立腺肥大症に伴う排尿障害に対する臨床効果および副作用について,91例,18施設の多施設臨床試験を実施した.試験は1週間以上の観察期,6週間の治療期とし,観察期および治療2週目,4週目,6週目に自覚症状,他覚所見(尿流量率,排尿量,残尿量)の変化を評価した.超音波断層法,尿道造影,CTスキャンなどで前立腺の推定重量を求め,前立腺の大きさと本剤の効果についても検討した.観察期にはプラセボ錠を投与し,治療は塩酸テラゾシン1 mg/日を初期投与量とし2週目で自覚症状が改善以上であれば1 mg/日の投与量を維持し,やや改善以下であれば2 mg/日に増量,4週目で改善以上であれば2 mg/日の投与量を維持し,やや改善以下であれば4 mg/日に増量し,6週目に最終効果判定をする.1 mg→2 mg→4 mgの漸増法とした.2)自覚症状の累積改善率は,1 mg/日では18.5%,2 mg/日までで55.6%,4 mg/日までで65.4%であった.観察期の自覚症状の強いものの方が症状の改善度が高く,治療終了時には自覚症状スコアは観察期のスコアにかかわらずほぼ同じレベルに収束した.3)自排尿量,最大尿流量率,平均尿流量率,残尿率,ノモグラムスコアは,いずれも治療後有意に改善した.残尿量,排尿開始までの時間については有意差はえられなかった.前立腺重量と最大尿流量率,ノモグラムスコアの改善度の間に有意な相関は認めなかった.他覚所見の累積改善率は,1 mg/日では13.2%,2 mg/日までで42.1%,4 mg/日までで50.0%であった.4)全般改善度の累積改善率は,1 mg/日14.5%,2 mg/日までで50.0%,4 mg/日までで61.8%であった.5)副作用は,ふらつき6件,立ちくらみ2件,耳鳴り,むかつき,かすみ目各1件の計11件(10例)で,発現率は11.6%であった.5例は臨床上問題なく服薬を継続し,1例は減量して服薬を継続した.服薬を中止したのは4例,4.7%であった.本薬に起因すると思われる臨床検査値異常は認められなかった.拡張期血圧の有意な低下を認めたが,収縮期血圧,脈拍に有意な変動を認めなかったja
dc.description.abstractIn this study the multicenter, fixed-flexible dose regimen was taken to evaluate the effective dose range of Terazosin for the treatment of micturition disturbance in benign prostatic hypertrophy (BPH) and to clarify the characteristics of patients who are more responsive to Terazosin therapy. After a 1-week washout (placebo) the first two weeks 1 mg/day of Terazosin was administered, then depending on efficacy of subjective symptoms, Terazosin doses were increased up to 2 mg/day and 4 mg/day at intervals of two weeks. After six weeks the final efficacy and safety were assessed. The subjective symptom improvement rate was 18.5% by 1 mg/day, 55.6% by 2 mg/day and 65.4% by 4 mg/day cumulatively. The objective symptom improvement rate were 13.2% by 1 mg/day, 42.1% by 2 mg/day and 50.0% by 4 mg/day cumulatively. The global improvement rate was 14.5% by 1 mg/day, 50.0% by 2 mg/day and 61.8% by 4 mg/day cumulatively. The patients who had a higher subjective symptom score in the lead-in period were more improved rather than those who had a lower score. In objective symptoms, voided volume, maximum flow rate (MFR), MFR nomogram score and average flow rate improved and the ratio of residual urine volume decreased. There was no relationship between clinical improvement on either subjective or objective symptoms and prostatic weight. Adverse reactions, such as dizziness, vertigo, tinnitus, nausea and blurred vision; were seen in 10 cases. In conclusion Terazosin was effective and well tolerated for the treatment of patients who had micturition disturbance with BPH in the dose range of 2 to 4 mg/day.ja
dc.format.mimetypeapplication/pdfja
dc.language.isojpnja
dc.publisher泌尿器科紀要刊行会ja
dc.subjectBenign prostatic hypertrophyja
dc.subjectTerazosin hydrochlorideja
dc.subjectFixed-flexible dose regimenja
dc.subjectMulticenter open studyja
dc.subjectalpha blockerja
dc.subject.ndc494.9ja
dc.title前立腺肥大症に伴う排尿障害に対する塩酸テラゾシンの臨床的検討 : 漸増法による多施設共同オープン試験ja
dc.title.alternativeA multicenter, fixed-flexible dose study of terazosin hydrochloride in the treatment of symptomatic benign prostatic hypertrophyja
dc.type.niitypeDepartmental Bulletin Paperja
dc.identifier.ncidAN00208315ja
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume38ja
dc.identifier.issue7ja
dc.identifier.spage857ja
dc.identifier.epage868ja
dc.textversionpublisherja
dc.sortkey21ja
dc.address近畿大学医学部泌尿器科学教室ja
dc.address近畿大学医学部泌尿器科学教室ja
dc.address近畿大学医学部泌尿器科学教室ja
dc.address耳原総合病院泌尿器科ja
dc.address泉大津市立病院泌尿器科ja
dc.address滋賀医科大学泌尿器科学教室ja
dc.address滋賀医科大学泌尿器科学教室ja
dc.address公立高島病院泌尿器科ja
dc.address市立守山市民病院泌尿器科ja
dc.address大阪医科大学泌尿器科学教室ja
dc.address大阪医科大学泌尿器科学教室ja
dc.address高槻赤十字病院泌尿器科ja
dc.address北摂病院泌尿器科ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大阪市立大学医学部泌尿器科学教室ja
dc.address大野記念病院泌尿器科ja
dc.addressPL病院泌尿器科ja
dc.address兵庫医科大学泌尿器科学教室ja
dc.address兵庫医科大学泌尿器科学教室ja
dc.address兵庫医科大学泌尿器科学教室ja
dc.address宝塚市立病院泌尿器科ja
dc.address神戸大学医学部泌尿器科学教室ja
dc.address神戸大学医学部泌尿器科学教室ja
dc.address神戸大学医学部泌尿器科学教室ja
dc.address関西労災病院泌尿器科ja
dc.address国立神戸病院泌尿器科ja
dc.address.alternativethe Department of Urology, School of Medicine, Kinki Universityja
dc.address.alternativethe Department of Urology, School of Medicine, Kinki Universityja
dc.address.alternativethe Department of Urology, School of Medicine, Kinki Universityja
dc.address.alternativethe Department of Urology, Mimihara General Hospitalja
dc.address.alternativethe Department of Urology, Izumiohtsu City Hospitalja
dc.address.alternativethe Department of Urology, Shiga University of Medical Scienceja
dc.address.alternativethe Department of Urology, Shiga University of Medical Scienceja
dc.address.alternativethe Department of Urology, Takashima General Hospitalja
dc.address.alternativethe Department of Urology, Moriyama City Hospitalja
dc.address.alternativethe Departmant of Urology, Osaka Medical Schoolja
dc.address.alternativethe Departmant of Urology, Osaka Medical Schoolja
dc.address.alternativethe Departmant of Urology, Takatsuki Red Cross Hospitalja
dc.address.alternativethe Department of Urology, Hokusctsu Hospitalja
dc.address.alternativethe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativethe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativethe Department of Urology, Osaka City University Medical Schoolja
dc.address.alternativethe Departmant of Urology, Ohno Memorial Hospitalja
dc.address.alternativethe Departmant of Urology, Hyogo College of Medicineja
dc.address.alternativethe Departmant of Urology, Hyogo College of Medicineja
dc.address.alternativethe Departmant of Urology, Hyogo College of Medicineja
dc.address.alternativethe Departmant of Urology, Takarazuka City Hospitalja
dc.address.alternativethe Department of Urology, Kobe University School of Medicineja
dc.address.alternativethe Department of Urology, Kobe University School of Medicineja
dc.address.alternativethe Department of Urology, Kobe University School of Medicineja
dc.address.alternativethe Departmant of Urology, Kansai Rousai Hospitalja
dc.address.alternativethe Department of Urology, P L Hospitalja
dc.address.alternativethe Department of Urology, Kobe National Hospitalja
dc.identifier.pmid1381869ja
Appears in Collections:Vol.38 No.7

Show simple item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.