塩酸テロジリンの頻尿,尿失禁に対する臨床的検討および心循環器系副作用

Abstract

1)慢性膀胱炎, 慢性前立腺炎, 前立腺肥大症の術後などに基づくと考えられる頻尿, 尿失禁を訴える患者109例を対象に塩酸テロジリンの有用性を検討した.2)最終全般改善度は92.7%であった.3)安全度は97.3%であった.4)有用度は91.8%であったが, 9例に副作用を認め, そのうち4例は投与中止に至った

We evaluated the effectiveness and side effects of terodiline hydrochloride in 109 patients with urinary frequency and urinary incontinence. The drug was administered at a dose of 24 mg once a day or 12 mg twice a day for 4 weeks. Symptoms such as urinary frequency and urinary incontinence were alleviated in 101 out of 109 patients (92.7%). Mild side effects such as thirst, dysuria, sense of residual urine, orthostatic hypotension and arrhythmia were observed in 9 out of 109 patients (8.2%). Side effects such as orthostatic hypotension and arrhythmia were observed on the 28th day or the 20th day of the administration, but these symptoms disappeared with discontinued use of this medicine. The results obtained from this study suggest that terodiline hydrochloride may be greatly useful for the patients with urinary frequency and urinary incontinence. But we must take account of the side effects such as orthostatic hypotension and arrhythmia.