Lomefloxacin 3日間連続投与後の前立腺組織内濃度について

Abstract

LFLXは治療的に連続して投与された場合に, 単回投与に比べて, 血中および前立腺組織内の濃度が上昇しているため, これらの組織内に蓄積される傾向があると考えられた。LFLXの前立腺組織内濃度を測定した結果, グラム陽性菌の大部分の菌株のMICと, グラム陰性菌ほとんどすべてのMICを, 200mg最終投与後約17時間の平均値でもかなり大幅に上回っていた

The penetration of Lomefloxacin (LFLX) into the prostatic tissue and the serum were examined. Forty four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate (TUR-P) were entered in this study. LFLX was administered orally in a dose of 200 mg three times daily for three days preoperatively. The blood samples were taken simultaneously at the time of the tissue sampling. The patients were divided into groups 1 and 2. In group 1 (seventeen patients), the tissue sampling was done about 17 hours after the final drug administration. The mean concentration of LFLX was 3.31 +/- 1.16 micrograms/g in the prostatic tissue and 1.70 +/- 0.56 micrograms/ml in the serum. In group 2 (twenty seven patients), tissue sampling was done 5.5 hours after the final drug administration. The mean concentration of LFLX was 5.70 +/- 2.28 micrograms/g in the prostatic tissue and 2.93 +/- 1.14 micrograms/ml in the serum.