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タイトル: | 進行前立腺癌(D2)例の治療前予後因子の検討 |
その他のタイトル: | Clinical assessments on pre-treatment prognostic factors in 138 patients with advanced prostatic carcinoma (stage D2) |
著者: | 加藤, 幹雄 岡田, 耕市 山科, 元章 当真, 嗣裕 石渡, 大介 東, 四雄 大和田, 文雄 |
著者名の別形: | Kato, Mikio Okada, Koichi Yamashina, Motoaki Tohma, Tsuguhiro Ishiwata, Daisuke Higashi, Yotsuo Ohwada, Fumio |
キーワード: | Advanced prostatic carcinoma Prognostic factors |
発行日: | Feb-1993 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 39 |
号: | 2 |
開始ページ: | 131 |
終了ページ: | 134 |
抄録: | D2例の予後を診断時点で推定する場合, 全身状態, 組織学的異型度が部分的には参考になりうるものの十全ではなく, さらに核異型の判定や, 治療後一定期間の十分な観察を加味して予後推定を行っていくことが必要である We investigated the prognostic factors in 138 patients with stage D2 prostatic cancer by univariate and multivariate analyses. Analysis was restricted to 8 pre-treatment parameters, that is, age, general condition (PS), pain, number of metastases on bone scan, acid phosphatase value, Gleason's primary pattern, secondary pattern, and nucleoli grading. In addition, 4 therapeutic modalities except routine endocrine therapy, that is, castration, oral administration of estramustine phosphate, of 5-fluorouracil (5-FU) or its analogue, and combination chemotherapy, during the whole treatment period were included in the analysis. Univariate analysis (Kaplan-Meier method) showed only PS to be a significant prognostic factor. Multivariate analysis (Cox's proportional hazard model) revealed that PS, Gleason's primary pattern, oral administration of 5-FU or its analogue and combination chemotherapy were significant prognostic factors. However, patients treated by combination chemotherapy had poorer prognosis and chi 2 values of combination chemotherapy was the highest among the four parameters cited above. These results suggested that the 8 pre-treatment parameters examined in this study were not sufficient for predicting the prognosis of each patient. |
URI: | http://hdl.handle.net/2433/117784 |
PubMed ID: | 8465686 |
出現コレクション: | Vol.39 No.2 |
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