表在性乳頭状膀胱腫瘍初発時における多部位粘膜生検の臨床的意義について

Abstract

表在性乳頭状膀胱腫瘍初発例71例に多部位粘膜生検を施行し, 10例(14%)になんらかの異型性変化を認めた。主腫瘍病変の性状との関係を見ると, 生検での異常所見例は全例G2以上で, pTa(9%)よりpTl(21%)に多かった。単発例(3%)より多発例(26%)に有意に多かった

We assessed the clinical significance of multiple mucosal biopsies in new cases of superficial papillary bladder tumor. Biopsy findings were abnormal (5 dysplasia, 5 transitional carcinoma) in 10 of the 71 cases examined. Abnormalities were observed exclusively at G2 or G3, and more frequently at pT1 than pTa. Cases with multiple tumors showed significantly more abnormalities than cases with a solitary tumor. Recurrence rates were not significantly different between the cases with abnormal biopsy findings and those with normal findings. However, the invasive tumor developed more frequently in the former. Mucosal biopsies seemed to be more useful in cases with multiple tumors than in those with a solitary tumor.