残存腫瘍にインターフェロンが著効を示した腎細胞癌の1例

Abstract

無症候性血尿, 右上腹部痛, 右側腹部腫瘤を訴えた53歳男で, 腫瘍血栓を伴う右腎細胞癌と診断し, 右腎摘出術を行ったが, 腫瘍の一部が腸腰筋に強固に癒着しているため, 治癒手術は不可能であった。遺残腫瘍は第二腰椎に広がり, 患者は腰痛を訴えた。腫瘍は発育を続け, 天然型インターフェロンの32週間に亙る投与に拘わらず, 対麻痺を来した。組換インターフェロンα2a 9×106単位を1週間に3回投与した所, 13週間後腫瘍は86.5%縮小し, 歩行可能となり, 部分寛解は17ヵ月間続いた

A 53-year-old man complaining of pain in his right upper abdomen was diagnosed as suffering from right renal cell carcinoma with tumor thrombus. Right nephrectomy was performed but curative operation was not possible because of the adhesion of the tumor to psoas muscle. The residual tumor spread to the second lumbar vertebra and the patient complained of lumbago. The tumor continued to grow and the patient suffered from paraplegia even after the administration of natural interferon for 32 weeks. The administration of 9 x 10(6) units of recombinant interferon alfa 2a three times a week, however, resulted in an 86.5% reduction of the tumor after 13 weeks and the patient between able to walk. The PR continued for 17 months.