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DCフィールド | 値 | 言語 |
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dc.contributor.author | 阿曽, 佳郎 | ja |
dc.contributor.author | 赤座, 英之 | ja |
dc.contributor.author | 亀山, 周二 | ja |
dc.contributor.author | 熊本, 悦明 | ja |
dc.contributor.author | 折笠, 精一 | ja |
dc.contributor.author | 佐藤, 仁 | ja |
dc.contributor.author | 小磯, 謙吉 | ja |
dc.contributor.author | 田崎, 寛 | ja |
dc.contributor.author | 岸本, 孝 | ja |
dc.contributor.author | 川地, 義雄 | ja |
dc.contributor.author | 岩田, 真二 | ja |
dc.contributor.author | 穂坂, 正彦 | ja |
dc.contributor.author | 長山, 忠雄 | ja |
dc.contributor.author | 河田, 幸道 | ja |
dc.contributor.author | 岡島, 英五郎 | ja |
dc.contributor.author | 園田, 孝夫 | ja |
dc.contributor.author | 大森, 弘之 | ja |
dc.contributor.author | 松村, 陽右 | ja |
dc.contributor.author | 小柳, 知彦 | ja |
dc.contributor.author | 舟生, 富寿 | ja |
dc.contributor.author | 山中, 英寿 | ja |
dc.contributor.author | 白岩, 康夫 | ja |
dc.contributor.author | 河合, 恒雄 | ja |
dc.contributor.author | 大島, 博幸 | ja |
dc.contributor.author | 北川, 龍一 | ja |
dc.contributor.author | 高須, 秀彦 | ja |
dc.contributor.author | 町田, 豊平 | ja |
dc.contributor.author | 島崎, 淳 | ja |
dc.contributor.author | 布施, 秀樹 | ja |
dc.contributor.author | 井坂, 茂夫 | ja |
dc.contributor.author | 岡田, 謙一郎 | ja |
dc.contributor.author | 三宅, 弘治 | ja |
dc.contributor.author | 吉田, 修 | ja |
dc.contributor.author | 古武, 敏彦 | ja |
dc.contributor.author | 難波, 克一 | ja |
dc.contributor.author | 宮川, 征男 | ja |
dc.contributor.author | 城仙, 泰一郎 | ja |
dc.contributor.author | 斎藤, 泰 | ja |
dc.contributor.author | 碓井, 亞 | ja |
dc.contributor.author | 熊澤, 浄一 | ja |
dc.contributor.author | 大井, 好忠 | ja |
dc.contributor.alternative | Aso, Yoshio | en |
dc.contributor.alternative | Akaza, Hideyuki | en |
dc.contributor.alternative | Kameyama, Syuji | en |
dc.contributor.alternative | Kumamoto, Yoshiaki | en |
dc.contributor.alternative | Origasa, Seiichi | en |
dc.contributor.alternative | Sato, Hitoshi | en |
dc.contributor.alternative | Koiso, Kenkichi | en |
dc.contributor.alternative | Tazaki, Hiroshi | en |
dc.contributor.alternative | Kishimoto, Takashi | en |
dc.contributor.alternative | Kawachi, Yoshio | en |
dc.contributor.alternative | Iwata, Shinji | en |
dc.contributor.alternative | Hosaka, Masahiko | en |
dc.contributor.alternative | Nagayama, Tadao | en |
dc.contributor.alternative | Kawada, Yukimichi | en |
dc.contributor.alternative | Okajima, Eigoro | en |
dc.contributor.alternative | Sonoda, Takao | en |
dc.contributor.alternative | Ohmori, Hiroyuki | en |
dc.contributor.alternative | Matsumura, Yosuke | en |
dc.contributor.alternative | Koyanagi, Tomohiko | en |
dc.contributor.alternative | Funyu, Tomihisa | en |
dc.contributor.alternative | Yamanaka, Hidetoshi | en |
dc.contributor.alternative | Shiraiwa, Yasuo | en |
dc.contributor.alternative | Kawai, Tsuneo | en |
dc.contributor.alternative | Oshima, Hiroyuki | en |
dc.contributor.alternative | Kitagawa, Ryuichi | en |
dc.contributor.alternative | Takasu, Hidehiko | en |
dc.contributor.alternative | Machida, Toyohei | en |
dc.contributor.alternative | Shimazaki, Jun | en |
dc.contributor.alternative | Fuse, Hideki | en |
dc.contributor.alternative | Isaka, Shigeo | en |
dc.contributor.alternative | Okada, Kenichiro | en |
dc.contributor.alternative | Miyake, Koji | en |
dc.contributor.alternative | Yoshida, Osamu | en |
dc.contributor.alternative | Kotake, Toshihiko | en |
dc.contributor.alternative | Nanba, Katsuichi | en |
dc.contributor.alternative | Miyagawa, Ikuo | en |
dc.contributor.alternative | Josen, Taiichiro | en |
dc.contributor.alternative | Saito, Yutaka | en |
dc.contributor.alternative | Usui, Tsuguru | en |
dc.contributor.alternative | Kumazawa, Joichi | en |
dc.contributor.alternative | Ooi, Yoshitada | en |
dc.date.accessioned | 2010-06-01T03:16:32Z | - |
dc.date.available | 2010-06-01T03:16:32Z | - |
dc.date.issued | 1993-04 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/117812 | - |
dc.description.abstract | 1)内分泌療法未治療の前立腺癌症例に対し, 375mg/日の用量で単独療法として使用しえる。この際, testosterone産生阻害療法に比し, 「生活の質」が保たれる。2)内分泌療法再燃例に対しても, ある程度その効果が期待できる。3)フルタミドと他の精巣性testosterone阻害剤との併用で, その併用効果が期待できる。4)また, LH-RHアナログの投与によるflare-up現象をフルタミドを併用することにより予防することが可能である | ja |
dc.description.abstract | The phase II study of flutamide, a pure anti-androgen, was performed to estimate the clinical doses on 165 hormone untreated or treated patients with prostatic cancer. The hormone-untreated patients were given orally flutamide of 90, 375, 750 or 1, 125 mg/day in three divided doses daily for 12 weeks. Responses were not observed at the 90 mg/day dose except for improvement of clinical symptoms. However, an objective response rate of 48.8-46.7% was obtained at 375-1, 125 mg/day doses. In hormone-treated patients including cases refractory to the previous hormonal treatment, the objective response rates were 13.3 and 8.3% in 375 and 750 mg/day flutamide groups, respectively. Side effects such as gynecomastia, nausea, vomiting, diarrhea, and abnormal laboratory findings such as the elevation of hepatic transaminases were observed. The incidence increased dose-dependently. Determinations of serum hormone levels revealed an increase in testosterone levels by the use of flutamide. In conclusion 375 mg/day of flutamide is the optimal dose in monotherapy for hormone-untreated patients with prostatic cancer, where the quality of life can be maintained compared with therapies involving testosterone suppression. This dose is also expected to show some efficacy in cases refractory to hormone treatment. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Prostatic cancer | en |
dc.subject | Flutamide | en |
dc.subject | Phase II study | en |
dc.subject.ndc | 494.9 | - |
dc.title | 非ステロイド性抗アンドロゲン剤フルタミドの前立腺癌に対する治療効果第2相用量設定試験 | ja |
dc.title.alternative | Clinical evaluation of flutamide, a pure antiandrogen, in prostatic cancer phase II dose-finding study | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 391 | - |
dc.identifier.epage | 403 | - |
dc.textversion | publisher | - |
dc.sortkey | 18 | - |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 東京大学医学部泌尿器科学教室 | ja |
dc.address | 札幌医科大学泌尿器科学教室 | ja |
dc.address | 東北大学医学部泌尿器科学教室 | ja |
dc.address | 群馬県立がんセンター泌尿器科 | ja |
dc.address | 筑波大学医学専門学群泌尿器科学教室 | ja |
dc.address | 慶応義塾大学医学部泌尿器科学教室 | ja |
dc.address | 日本大学医学部泌尿器科学教室 | ja |
dc.address | 順天堂大学浦安病院泌尿器科 | ja |
dc.address | 葛南病院泌尿器科 | ja |
dc.address | 横浜市立大学医学部泌尿器科学教室 | ja |
dc.address | 千葉県がんセンター泌尿器科 | ja |
dc.address | 岐阜大学医学部泌尿器科学教室 | ja |
dc.address | 奈良県立医科大学泌尿器科学教室 | ja |
dc.address | 大阪大学医学部泌尿器科学教室 | ja |
dc.address | 岡山大学医学部泌尿器科学教室 | ja |
dc.address | 岡山大学医学部泌尿器科学教室 | ja |
dc.address | 北海道大学医学部泌尿器科学教室 | ja |
dc.address | 弘前大学医学部泌尿器科学教室 | ja |
dc.address | 群馬大学医学部泌尿器科学教室 | ja |
dc.address | 福島県立医科大学泌尿器科学教室 | ja |
dc.address | (財)癌研究会付属病院泌尿器科 | ja |
dc.address | 東京医科歯科大学医学部泌尿器科学教室 | ja |
dc.address | 順天堂大学医学部泌尿器科学教室 | ja |
dc.address | 越谷市民病院泌尿器科 | ja |
dc.address | 東京慈恵会医科大学泌尿器科学教室 | ja |
dc.address | 千葉大学医学部泌尿器科学教室 | ja |
dc.address | 千葉大学医学部泌尿器科学教室 | ja |
dc.address | 千葉大学医学部泌尿器科学教室 | ja |
dc.address | 福井医科大学泌尿器科学教室 | ja |
dc.address | 名古屋大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 大阪府立成人病センター泌尿器科 | ja |
dc.address | 岡山市立市民病院泌尿器科 | ja |
dc.address | 鳥取大学医学部泌尿器科学教室 | ja |
dc.address | 広島市民病院泌尿器科 | ja |
dc.address | 長崎大学医学部泌尿器科学教室 | ja |
dc.address | 広島大学医学部泌尿器科学教室 | ja |
dc.address | 九州大学医学部泌尿器科学教室 | ja |
dc.address | 鹿児島大学医学部泌尿器科学教室 | ja |
dc.address.alternative | the Department of Urology, Faculty of Medicine, University of Tokyo | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, University of Tokyo | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, University of Tokyo | en |
dc.address.alternative | the Department of Urology, School of Medicine, Hokkaido University | en |
dc.address.alternative | the Department of Urology, Sapporo Medical College | en |
dc.address.alternative | the Department of Urology, School of Medicine, Hirosaki University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Tohoku University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Gunma University | en |
dc.address.alternative | the Department of Urology, Gunma Cancer Center | en |
dc.address.alternative | the Department of Urology, Fukushima Medical College | en |
dc.address.alternative | the Department of Urology, Institute of Clinical Medicine, University of Tsukuba | en |
dc.address.alternative | the Department of Urology, Cancer Institute Hospital | en |
dc.address.alternative | the Department of Urology, School of Medicine, Keio University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Tokyo Medicaland Dental University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Nihon University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Juntendo University | en |
dc.address.alternative | the Department of Urology, Urayasu Hospital, Juntendo University | en |
dc.address.alternative | the Department of Urology, Koshigaya- Shimin Hospital | en |
dc.address.alternative | the Department of Urology, Katsunan Hospital | en |
dc.address.alternative | the Department of Urology, the Jikei University School of Medicin | en |
dc.address.alternative | the Department of Urology, Yokohama City University School of Medicine | en |
dc.address.alternative | the Department of Urology, School of Medicine, Chiba University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Chiba University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Chiba University | en |
dc.address.alternative | the Department of Urology, Chiba Cancer Center | en |
dc.address.alternative | the Department of Urology, Fukui Medical School | en |
dc.address.alternative | the Department of Urology, School of Medicine, Gifu University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Nagoya University | en |
dc.address.alternative | the Department of Urology, Nara Medical University | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Urology, Osaka University Medical School | en |
dc.address.alternative | the Department of Urology, the Centerfor Adult Diseases, Osaka | en |
dc.address.alternative | the Department of Urology, School of Medicine, Okayama University | en |
dc.address.alternative | the Department of Urology, School of Medicine, Okayama University | en |
dc.address.alternative | the Department of Urology, Okayama Shimin Hospital | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Tottori University | en |
dc.address.alternative | the Department of Urology, Hiroshima University School of Medicine | en |
dc.address.alternative | the Department of Urology, Hiroshima- Shimin Hospital | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyushu University | en |
dc.address.alternative | the Department of Urology, Nagasaki University School of Medicine | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kagoshima University | en |
dc.identifier.pmid | 8503339 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.39 No.4 |
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