腎細胞癌患者の免疫能におよぼす遺伝子組換えインターフェロンγの影響

Abstract

1)IFN-γの投与により, 原発巣浸潤リンパ球サブセットは非投与群に比較してCD8, CD11bが有意に上昇し, CD3, CD4も有意ではないが上昇する傾向がみられた。2)IFN-γの投与により, 投与前に比較してADCC活性は有意に上昇し, NK活性も有意ではないが上昇する傾向が認められた。特に, high stage症例で両者の活性は, 投与前および非投与群と比較しても上昇する傾向がみられ, high stage症例でのIFN-γの手術前投与の有用性を示唆する

The immunological effect of interferon-gamma (IFN-gamma) was investigated in 18 cases of renal cell carcinoma before and after the operation. In 6 patients, IFN-gamma was administered preoperatively for 21 days (administration group), while 12 patients underwent nephrectomy alone without preoperative treatment (control group). The peripheral immunological effects were measured at before and 12 days after the operation in the administration group and at 11 days in the control group. In the administration group, a marked increase was noted in the test of antibody dependent cell-mediated cytotoxicity (ADCC) activity and natural killer (NK) activity, and slight increase in CD4/8 and CD11b. In low stage cases, no appreciable effect was obtained by the administration of IFN-gamma. However, in high stage cases, IFN-gamma tended to increase the value of ADCC activity and NK activity. Immunohistochemical studies of tumor infiltrating lymphocytes in renal cell carcinoma showed a high incidence of CD8 and CD11b in the administration group. Moreover, the presence of CD8 was higher than that of CD4 in the administration group in contrast to the results of the peripheral blood analysis.