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Title: ラット雄性副性器の腺管上皮および間質のホルモン反応特性
Other Titles: The characteristics of hormone responsiveness of glandular epithelium and stroma in male accessory sex organs
Authors: 湯浅, 久子  KAKEN_name
深堀, 能立  KAKEN_name
真下, 透  KAKEN_name
大間, 千賀子  KAKEN_name
鈴木, 孝憲  KAKEN_name
山中, 英寿  KAKEN_name
鈴木, 慶二  KAKEN_name
Author's alias: Yuasa, Hisako
Fukabori, Yoshitatsu
Mashimo, Tohru
Ohma, Chikako
Suzuki, Takanori
Yamanaka, Hidetoshi
Suzuki, Keiji
Keywords: Prostate
Seminal vesicle
Sex hormones
Issue Date: Jul-1993
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 39
Issue: 7
Start page: 631
End page: 637
Abstract: 前立腺および精嚢の腺管と間質がアンドロジェン・エストロジェンに対してどのような反応特性を持っているかについて思春期前去勢ラットを用いて検討した。1)アンドロジェンは思春期前去勢ラットの前立腺および精嚢の腺管上皮の増殖と分化を促すのみならず,間質コラーゲンの合成と蓄積を促すという諸家らの報告を再確認した。2)エストロジェン2週投与時の前立腺側背葉の腺管上皮細胞層は腹葉や精嚢に比べてより厚く,2~3層に重層していた。しかし,細胞の分化の指標であるアンドロジェン依存性蛋白・EMBPの合成促進はなかった。すなわち,エストロジェンは副性器の腺管上皮の増殖を促し,その強さは臓器によって異なっていた。3)エストロジェン2週投与は前立腺および精嚢の間質コラーゲンを増加させた。増加の度合いは前立腺腹葉<前立腺側背葉<精嚢であり,精嚢の反応が前立腺に比べて著しかった。4)エストロジェン投与時の精嚢の組織像はコラーゲン・平滑筋の増加が著しく,ヒト線維筋腫型肥大症のそれと非常に類似した。ヒト前立腺肥大症の動物モデルが少ない現在,有用な実験モデルとなる可能性が示唆された
We investigated the hormonal responsiveness of gland and stroma in the male accessory sex organs (ventral prostate, dorsolateral prostate and seminal vesicle). Immature rats (3 weeks old) were castrated and left untreated for 4 weeks and then distributed at random into 3 groups, A, B, C. The rats in groups A, B and C were injected subcutaneously with 0.2 ml of soybean oil, 5 alpha-dihydrotestosterone (DHT, 500 micrograms/day) or estradiol-17 beta (E2-17 beta, 5 micrograms/day), respectively, for 14 days before they were killed. DHT administration in prepuberal castrates stimulated collagen synthesis and accumulation in the stroma of male accessory sex organs as well as the proliferation and differentiation of the glandular epithelium in these organs. In E2-17 beta treated rats, the glandular epithelium of ventral prostate and seminal vesicle had mostly a single layer structure, but the glandular epithelium of dorsolateral prostate had a mostly multilayer structure. On the other hand, in E2-17 beta treated rats, the EMBP content, an indicator of glandular epithelium differentiation in male accessory sex organs, did not increase even in the dorsolateral prostate which showed a multilayer gland epithelium. Collagen synthesis and accumulation in the seminal vesicle was stimulated by E2-17 beta treatment several times as much as in the ventral and dorsolateral prostate. Histological investigation demonstrated that the seminal vesicle in prepuberal castrates treated with E2-17 beta resembled that of fibromuscular type human benign prostatic hyperplasia.
PubMed ID: 8362682
Appears in Collections:Vol.39 No.7

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