前立腺癌の臨床的検討

Abstract

1986年から5年間に入院した未治療前立腺癌75症例を対象に検討を行った。初診時の年齢は52～90歳(平均72.3歳)で, 主訴は排尿障害が73%であったが, その他は多彩であった。32症例は喫煙者であった。成人疾患を多く合併していた。T1が18例, T2が10例, T3が29例およびT4が18例で, G1が28例, G2が29例, G3が11例, G4が7例であった。T分類, G分類ともに年齢と相関はしなかった。腫瘍マーカーの感度はPAが最も高かったが, どのマーカーもT3およびT4症例では感度が高くなっていた。74例に抗男性ホルモン療法が行われた。T分類とM分類には生存率に有意差をみとめたが, G分類, 年齢, マーカーにより生存率有意差は認めなかった。G2症例に限定すれば放射線療法で予後が改善される可能性が示唆された

A clinical study was performed on 75 patients with untreated prostatic cancer who had been hospitalized over a 5-year period. The age range was 52 to 90 years (median age: 72.3 years). The main complaint was dysuria in 73% of the cases. Thirty-two (43%) patients were smokers, and complications included bladder cancer in two and rectal cancer in one. The stages were T1 in 18 cases, T2 in 10, T3 in 29 and T4 in 18, 28 cases were G1, 29 were G2, 11 were G3 and seven were G4. Among the tumor markers, PA sensitivity was the highest, but all markers showed high sensitivities in the T3 and T4 cases. Endocrinological treatment was performed on 74 patients. Survival rates showed significant differences only for the T and M classifications; no significant differences in survival rates according to the G classification, age of the patient or tumor markers were observed. Radiotherapy was suggested to be related to improvements in the prognosis only in patients with histological grading of G2.