Paraparesis due to metastatic prostatic cancer effectively treated with a high dose of diethylstilbestrol diphosphate: a case report

Abstract

患者は78歳, 男性, 2ヵ月間の腰痛と両下肢麻痺にて来院.広範囲の骨転移を有する前立腺癌であった.parapareｓisの原因は, Th11-Th12の前立膿癌脊権骨転移によるspinalcordcompressionであった.大量のdiethylstilbestrol diphosphate投与にて著効を示し, 歩行可能となった.椎弓切除術, 放射線療法, 去勢, あるいはそれらの組み合わせがよいとする論文が最近多いが, 本例は, diethylstilbestroldiphos.phateit与のみで著効を示したので, その有用性につき考察した.

A case of paraparesis due to thoracic vertebula metastasis of prostate cancer is reported. Treatment through a high dose of diethylstilbestrol diphosphate (DES-P) was very effective. Two and a half years later, the patient is ambulatory and relapse has not occurred. We recommend the use of a high dose of DES-P for spinal cord compression due to prostate cancer, instead of laminectomy or radiation.