前立腺癌の危険因子に関する検討

Abstract

1)前立腺癌患者, 対照それぞれ294人に対して症例-対照研究を行った。それぞれの項目に対して69歳以下群, 70歳以上群に分けて, さらに全年齢群における年齢訂正O.R., 95%C.I.を算出した。2)前立腺癌のO.R.が有意に高かったものは, 1)農林, 漁業従事者である, 2)ひげそり3日に1回以下, 3)恥毛がうすい, 4)包茎である, 5)喫煙歴あり, 6)喫煙年数50年以上, 7)野菜の摂取がまれ, 8)喘息の既往または合併ありであった。前立腺肥大症, 前立腺炎, 尿道狭窄のO.R.が有意に高かった。家族に前立腺癌のいる数は, 患者4人に対して対照0人であった。3)前立腺癌O.R.が有意に低かったものは, 1)職業が事務従事者である, 2)血液型がA型またはAB型, 3)子どもの数が1人以下, 4)結核の既往または合併ありであった

A case-control study was conducted on 294 prostatic cancer patients and controls. General population controls were chosen from 13 areas in Gunma Prefecture and were matched by age (+/- 2 y.o.) to cases. Odds ratio (O.R.) and 95% confidence interval (C.I.) were calculated on each item according to group; 69 years old or younger and 70 years old or older, and age-adjusted O.R. and 95% C.I. were calculated. Risk factors of prostatic cancer were investigated. There was a significantly higher risk for prostatic cancer in those 1) engaged in agriculture, forestry or fishery ( or = 70, total), 2) shaving 1/3 days or less frequently (> or = 70, total), 3) having thin pubic hair (total), 4) phimosis ( or = 70, total), 6) history of smoking 50 years or more (total), 7) having eaten vegetables rarely (> or = 70, total), 8) having past history or complication of asthma (> or = 70). O.R.s of having past history or complication of benign prostatic hypertrophy, prostatitis and urethral stricture were high significantly, but they were supposed to be caused by bias. Four patients had first degree family members who suffered from prostatic cancer, compared to zero in the control. There was a significantly lower risk for prostatic cancer in those 1) engaged in office work (> or = 70, total), 2) blood type A or AB (< or = 69), 3) having had one child or none (total), 4) having past history or complication of tuberculosis (total).(ABSTRACT TRUNCATED AT 250 WORDS)