精巣腫瘍におけるTopo 1阻害剤のプラチナ化合物の効果増強について

Abstract

ヌードマウス可移植ヒト精巣腫瘍株を用い, CPT-11とCDDPなどのプラチナ化合物との併用療法により, 抗腫瘍効果の著しい増強がみられることを示した。この結果をふまえ, 4例の難治性精巣腫瘍に対しCPT-11とCDDPや254-Sによる併用療法を行い, 2例でその有効性が示された

The antitumor effects of combination chemotherapies using CDDP and the camptothecin analogue CPT-11 were compared with those of vinca alkaloids or podophyllotoxins, and those of CPT-11 and cisplatinum analogues were also estimated. Two human testicular cancer xenografts (TTSC -2 and TTSC-3) heterotransplanted in nude mice were used. Combination therapy with CPT-11 and CDDP resulted in significant tumor regression and was much more effective than that of CDDP and vinca alkaloids or podophyllotoxin. The combination of CPT-11 and either CDDP or 254-S was significantly more effective than that of CPT-11 and either carboplatin or DWA2114R. Four evaluable refractory testicular cancers were treated with combination chemotherapy with CPT-11 and CDDP or 254-S as third line chemotherapy. Two patients remain alive and disease free and two patients died of disease. We concluded that the present combination is active in refractory testicular cancer.