オフロキサシンの前立腺組織内移行

Abstract

前立腺肥大症15例に対し前立腺摘出術を行い, 採取した前立腺組織内におけるオフロキサシンの移行性について検討した。オフロキサシンの血清濃度と前立腺組織内濃度はほぼ同等であり, 前立腺炎のおもな臨床分離株のMIC80を越える値を示し, 急性・慢性前立腺炎に対しても有効と考えられた

The concentration of ofloxacin in prostatic tissue and serum was determined in order to evaluate the permeability of ofloxacin into prostatic tissue in patients with benign prostatic hypertrophy. Ofloxacin was administered orally at a dose of 200 mg several hours before subcapsular prostatectomy. The determination was performed in the surgically removed adenoma and in the serum taken one hour before and at the removal of the adenoma. The peak level in the prostatic tissue was 1.46 microgram/g at 4.5 hour after the administration. The ratio of prostatic tissue level to the serum level was 1.00. In conclusion, ofloxacin was thought to be very useful for the treatment of acute and chronic prostatitis.