セミノーマにおけるHCG陽性細胞について

Abstract

1)セミノーマ38例について間接immunoperoxidase法を用いてHCG様物質の局在を検索したところ5例(13%)にこれを認めた.2) HCG様物質の局在はいわゆるSTGCのほかに単核のセミノーマ細胞に類似の腫瘍細胞にも認められた.3) HCG値があきらかに陽性であるにもかかわらず, HCG陽性細胞が認められなかった症例が5例あったが, 検索した切片の数の不足が原因と考えられた.bulky stage 2の1例は癌死したが4例は健在である.4)セミノーマにおけるSTGCの存在あるいは軽度の血中あるいは尿中HCG値の上昇は, low stageであれば従来の放射線治療であれ, 化学療法であれ予後は良好と思われた

In a retrospective study of 38 patients with pure seminoma, serum and urine levels of human chorionic gonadotropin (HCG) were measured and the cellular origin of HCG-like substance was searched using the technique of indirect immunoperoxidase on step sections of the tumors. Eight of the patients had elevated HCG in serum or urine, and 5 had HCG-positive cells in the sections of tumor specimens. With this technique, two types of HCG-positive cells were identified, syncytiotrophoblastic giant cells (STGC) and mononuclear cells otherwise indistinguishable from seminoma cells. Patients in the present series responded well to conventional radiation therapy or cytotoxic chemotherapy and had a favorable outcome regardless of the presence of STGC or slightly elevated HCG levels.