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Title: 泌尿性器悪性腫瘍に合併した高カルシウム血症20例について
Other Titles: 20 Cases of Hypercalcemia Associated with Urogenital Malignancies
Authors: 東, 義人  KAKEN_name
川村, 寿一  KAKEN_name
金丸, 洋史  KAKEN_name
筧, 善行  KAKEN_name
吉田, 修  KAKEN_name
Author's alias: HIGASHI, Yoshihito
KAKEHI, Yoshiyuki
Keywords: Hypercalcemia
Urogenital malignancy
Eel calcitonin
Issue Date: May-1984
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 30
Issue: 5
Start page: 599
End page: 607
Abstract: 1) 1978年1月から6ヵ月間に,京大泌尿器科において入院治療をおこなった泌尿性器悪性腫瘍患者610名のうち,血清Ca値11.0 mg/dl以上の高Ca血症の合併をみたのは,20例(3.3%)であった.そのうちわけは,腎細胞癌62例中10例(16.1%),膀胱癌321例中6例(1.9%),腎盂尿管癌45例中3例(6.7%),前立腺癌95例中1例(1.1%)であった.2)高Ca血症に対し,原発病巣の手術的切除と,癌化学療法が有効であった.保存的療法として,輪液療法に加えて,インドメサシン,ステロイド剤,合成ウナギカルチトニンの単独あるいは併用投与をおこない,11例において平均3.7 mg/dlの低Ca効果を得た.しかし,血清Ca値の再上昇をきたしたものが多かった.3)手術をおこないえた腎癌の2例を除いて,18例いずれの症例も広範な遠隔転移あるいは局所の再発侵潤をきたしており,高Ca血症の出現後5日から9ヵ月(平均2ヵ月)の間に死亡した
Twenty cases (3.3%) of hypercalcemia of more than 11.0 mg/dl associated with urogenital malignancy were observed in 610 inpatients during the past 5 years and 6 months (Jan. 1978-June 1983). Incidences were 10 (16.1%) out of 62 cases of renal cell carcinoma, 6 (1.9%) out of 321 cases of bladder cancer, 3 (6.7%) out of 45 cases of renal pelvic and ureteral cancer, and one (1.1%) out of 95 cases of prostatic cancer. As treatment, surgery (radical nephrectomy) and anti-cancer chemotherapy were effective in 3 cases (2 renal cell carcinomas and one renal pelvic cancer). Conservative therapy with hydration combined with either indomethacin, steroid or eel calcitonin was effective in 11 cases, and s-Ca level was decreased by 3.7 mg/dl on the average. Eighteen patients were in the terminal stage of malignancy when hypercalcemia was observed, and died 5 days to 9 months (mean; 2 months) after the onset of hypercalcemia.
PubMed ID: 6475683
Appears in Collections:Vol.30 No.5

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