水素ガスクリアランス法による腎血流量の測定

Abstract

家兎で水素ガスクリアランス法を用い腎血流量を測定した.1)腎皮質, 傍髄質血流値はおのおの215.0±29.8, 145.6±26.3 ml/min/100 gであった.2)温阻血を加えた後, 阻血解除10分後の血流値は皮質, 傍髄質とも阻血30分群, 60分群, 120分群でほぼ阻血前値の約70%であった.3)温阻血30, 60, 120分後の腎内血流再分布は30, 60分群では認めず, 120分群で軽度に皮質血流量が低下した

The local renal blood flow in rabbits was determined by means of hydrogen gas clearance. Simultaneously, to clarify intrarenal redistribution during ischemic renal failure, renal vessels were occluded for some period. Namely, the rabbits were divided into three groups according to the duration of warm ischemia, which was 30, 60 and 120 minutes. The cortical and paramedullary blood flow were 215.0 +/- 29.8 and 145.6 +/- 26.3 ml/min/100 g, respectively, in the control group. In the three ischemic groups, each renal blood flow was only reduced by about 30% after 10 minutes following release of occlusion. In cases of ischemia of 30 or 60 minutes, no distinct intrarenal redistribution was seen. However, in 120 minute ischemia a slight decrement of cortical blood flow occurred after 40 minutes following release of clamp. Hydrogen gas clearance can be used to measure regional blood flow repeatedly. This method should be clinically applicable.